Conformational properties of oligonucleotides. Journal Article

Overview

abstract

• Vast libraries of oligonucleotide sequences can be made. Such libraries have been screened and/or selected to identify individual molecules showing various properties, including high affinity/high specificity binding (to something) or new enzymatic activity. The SELEX protocol is used to identify these interesting oligonucleotides; two recent reviews of the SELEX protocol and its power have appeared recently. Oligonucleotides derived through the SELEX process have applications in diagnostics and therapeutics, and have additional value as research reagents and compounds that provide chemical plausibility to some ideas about evolution of the biosphere. Oligonucleotide conformations are shockingly robust and potent.

CU Boulder Authors

• Gold, Larry

publication date

• January 1, 1995

has subject area

• Bacteriophages - Bacteriophage T4
• Biological Phenomena - Evolution, Molecular
• DNA
• DNA Viruses - Bacteriophage T4
• Genetic Phenomena - Evolution, Molecular
• Genetic Structures - Nucleic Acid Conformation
• Genetic Techniques
• Molecular Conformation - Nucleic Acid Conformation
• Mutagenesis
• Oligonucleotides
• T-Phages - Bacteriophage T4

Date in CU Experts

• September 9, 2013 9:29 AM

Full Author List

• Gold L

author count

• 1

published in

• Nucleic Acids Symposium Series  Journal

Other Profiles

International Standard Serial Number (ISSN)

• 0261-3166

Additional Document Info

start page

• 20

end page

• 22

issue

• 33