EVIDENCE THAT INTRATHECAL MORPHINE-3-GLUCURONIDE MAY CAUSE PAIN ENHANCEMENT VIA TOLL-LIKE RECEPTOR 4/MD-2 AND INTERLEUKIN-1 beta
Journal Article
Overview
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Animals
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Antigens, Surface - Antigens, CD11b
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Antigens, Surface - Lymphocyte Antigen 96
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Biological Factors - Interleukin-1beta
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Biological Factors - Interleukin-1beta
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Biomarkers - Antigens, CD11b
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Carrier Proteins - Lymphocyte Antigen 96
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Cells - Microglia
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Central Nervous System Agents - Central Nervous System Stimulants
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HSP90 Heat-Shock Proteins
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Heterocyclic Compounds, 4 or More Rings - Morphine Derivatives
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Heterocyclic Compounds, Bridged-Ring - Morphine Derivatives
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Injections, Spinal
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Integrin alpha Chains - Antigens, CD11b
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Male
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Nervous System - Microglia
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Nervous System Diseases - Hyperalgesia
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Nervous System Diseases - Pain
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Nervous System Physiological Phenomena - Pain
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Opiate Alkaloids - Morphine Derivatives
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Peptides - Interleukin-1beta
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Peptides - Interleukin-1beta
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Physiological Effects of Drugs - Central Nervous System Stimulants
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Polycyclic Compounds - Morphine Derivatives
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Proteins - Interleukin-1beta
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Proteins - Interleukin-1beta
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Psychological Phenomena and Processes - Pain
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RNA, Messenger
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Rats
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Rats, Sprague-Dawley
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Receptors, Complement - Antigens, CD11b
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Receptors, Interleukin-1
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Signs and Symptoms - Hyperalgesia
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Signs and Symptoms - Pain
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Spinal Cord
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Toll-Like Receptor 4
Full Author List
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Lewis SS; Hutchinson MR; Rezvani N; Loram LC; Zhang Y; Maier SF; Rice KC; Watkins LR
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