Characterization of individual ultrasound microbubble dynamics with a light-scattering system. Journal Article uri icon



  • Ultrasound microbubbles are contrast agents used for diagnostic ultrasound imaging and as carriers for noninvasive payload delivery. Understanding the acoustic properties of individual microbubble formulations is important for optimizing the ultrasound imaging parameters for improved image contrast and efficient payload delivery. We report here a practical and simple optical tool for direct real-time characterization of ultrasound contrast microbubble dynamics based on light scattering. Fourier transforms of raw linear and nonlinear acoustic oscillations, and microbubble cavitations are directly recorded. Further, the power of this tool is demonstrated by comparing clinically relevant microbubble cycle-to-cycle dynamics and their corresponding Fourier transforms.

publication date

  • June 1, 2011

has subject area

Full Author List

  • Hsu MJ; Eghtedari M; Goodwin AP; Hall DJ; Mattrey RF; Esener SC

Other Profiles

Additional Document Info

start page

  • 067002


  • 16


  • 6