selected publications
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journal article
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Two Classes of Myosin Inhibitors, Para-nitroblebbistatin and Mavacamten, Stabilize β-Cardiac Myosin in Different Structural and Functional States.
Journal of Molecular Biology.
2021
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Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function.
Science Advances.
2015
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The Python Project: A Unique Model for Extending Research Opportunities to Undergraduate Students.
CBE : Life Sciences Education.
698-710.
2014
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The Hypertrophic Cardiomyopathy Myosin Mutation R453C Alters ATP Binding and Hydrolysis of Human Cardiac β- Myosin*.
Journal of Biological Chemistry.
5158-5167.
2014
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Hydrogels preserve native phenotypes of valvular fibroblasts through an elasticity-regulated PI3K/AKT pathway.
Proceedings of the National Academy of Sciences of USA.
19336-19341.
2013
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Use of integrin-linked kinase to extend function of encapsulated pancreatic tissue.
Biomedical Materials.
2010
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A Mediator of Rho-dependent Invasion Moonlights as a Methionine Salvage Enzyme.
Molecular and Cellular Proteomics.
2308-2320.
2009
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Immunological priming potentiates non-viral anti-inflammatory gene therapy treatment of neuropathic pain.
Gene Therapy (Basingstoke).
1210-1222.
2009
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Immunogenicity of intrathecal plasmid gene delivery: cytokine release and effects on transgene expression.
Journal of Gene Medicine.
782-790.
2009
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Intrathecal Injection of Naked Plasmid DNA Provides Long-term Expression of Secreted Proteins.
Molecular Therapy.
88-94.
2009
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A randomized library approach to identifying functional lox site domains for the Cre recombinase.
Nucleic Acids Research.
5464-5473.
2007
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Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats.
Brain, Behavior, and Immunity.
686-698.
2007
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Student award winner in the undergraduate degree category for the society for biomaterials, 32nd Annual Meeting, Chicago, Illinois, April 17-20, 2007.
Journal of Biomedical Materials Research Part A.
259-268.
2007
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Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain.
Pain.
294-308.
2006
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Functional proteomics identifies protein-tyrosine phosphatase 1B as a target of RhoA signaling.
Molecular and Cellular Proteomics.
1359-1367.
2006
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ITRs Necessary for IL-10 Encoding Naked Plasmid Induced Reversal of Chronic Pain State in Rat.
Molecular Therapy.
S100-S100.
2006
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In Vivo Over-Expression of Fractalkine, a Putative Neuron-to-Glia Signal, To Characterize Underlying Mechanisms of Neuropathic Pain.
Molecular Therapy.
S100-S100.
2006
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Plasmid DNA Encoding the Anti-Inflammatory Cytokine Gene, Interleukin-10 (IL-10) for Chronic Pain Control: Taking Advantage of Nuclear Scaffold/Matrix Attachment Regions.
Molecular Therapy.
S99-S99.
2006
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Intrathecal polymer-based interleukin-10*gene delivery for neuropathic pain.
Neuron Glia Biology.
293-308.
2006
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Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10.
European Journal of Neuroscience.
2136-2148.
2005
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Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10.
Molecular Pain.
2005
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The Ku protein complex interacts with YY1, is up-regulated in human heart failure, and represses α myosin heavy-chain gene expression.
Molecular and Cellular Biology.
8705-8715.
2004
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A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine.
The Journal of Neuroscience.
7353-7365.
2004
- Spinal interleukin-10 (IL-10) gene therapy using viral and non-viral vectors controls inflammatory- and chronic constriction injury-induced pain states in rats. Molecular Therapy. S200-S201. 2004
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Rational promoter selection for gene transfer into cardiac cells.
Journal of Molecular and Cellular Cardiology.
823-831.
2003
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Acute effects of desmin mutations on cytoskeletal and cellular integrity in cardiac myocytes.
Cytoskeleton.
105-121.
2003
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A genetic screen identifies novel non-compatible IoxP sites.
Nucleic Acids Research.
3067-3077.
2002
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Potential limitations of transcription terminators used as transgene insulators in adenoviral vectors.
Gene Therapy (Basingstoke).
227-231.
2002
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Potential limitations of transcription terminators used as transgene insulators in adenoviral vectors..
Gene Therapy (Basingstoke).
227-231.
2002
- Overexpression of the plasma membrane calcium ATPase isoform 4b dose-dependently affects growth and survival of neonatal rat cardiomyocytes. Circulation. 137-137. 2001
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Two Classes of Myosin Inhibitors, Para-nitroblebbistatin and Mavacamten, Stabilize β-Cardiac Myosin in Different Structural and Functional States.
Journal of Molecular Biology.
2021