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Old, William Assistant Professor

Positions

Research Areas research areas

Research

research overview

  • Dr. Old is interested in the signaling networks that regulate cell growth, development and communication in multicellular organisms, and how defects in these networks drive cancer and neurodevelopmental disorders. Of particular interest is how kinases integrate extracellular signals with transcription, mRNA splicing, and pathways that control growth and patterning. On a technological front, Dr. Old's lab is developing advanced mass spectrometry methods and multi-omic integrative approaches to facilitate the identification of molecular mechanism of action of new therapeutic drugs and small molecules with poorly understood mechanisms. Using new stem cell derived model systems, they are applying these technologies to understand the molecular basis for altered neurodevelopment in Down syndrome, and the role of DYRK1A in neuronal development, tissue-specific transcription, and splicing.

keywords

  • systems biology, proteomics, metabolomics, signal transduction, cancer, brain development, cerebral organoids

Publications

selected publications

Teaching

courses taught

  • CHEM 6901 Research in Chemistry (Spring 2019)
  • CHEM 8991 Doctoral Dissertation (Spring 2019)
  • MCDB 6000 Introduction to Laboratory Methods (Spring 2019)
  • MCDB 8990 Doctoral Dissertation (Spring 2019)
  • CHEM 6901 Research in Chemistry (Fall 2018)
  • MCDB 2150 Principles of Genetics (Fall 2018)
  • MCDB 8990 Doctoral Dissertation (Fall 2018)
  • CHEM 6901 Research in Chemistry (Spring 2018)
  • CHEM 8991 Doctoral Dissertation (Spring 2018)
  • MCDB 6000 Introduction to Laboratory Methods (Spring 2018)
  • MCDB 8990 Doctoral Dissertation (Spring 2018)

Background

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