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Publications in VIVO

Old, William Assistant Professor


Research Areas research areas


research overview

  • Dr. Old is interested in the signaling networks that regulate cell growth, development and communication in multicellular organisms, and how defects in these networks drive cancer and neurodevelopmental disorders. Of particular interest is how kinases integrate extracellular signals with transcription, mRNA splicing, and pathways that control growth and patterning. On a technological front, Dr. Old's lab is developing advanced mass spectrometry methods and multi-omic integrative approaches to facilitate the identification of molecular mechanism of action of new therapeutic drugs and small molecules with poorly understood mechanisms. Using new stem cell derived model systems, they are applying these technologies to understand the molecular basis for altered neurodevelopment in Down syndrome, and the role of DYRK1A in neuronal development, tissue-specific transcription, and splicing.


  • systems biology, proteomics, metabolomics, signal transduction, cancer, brain development, cerebral organoids


selected publications


courses taught

  • CHEM 6901 - Research in Chemistry
    Primary Instructor - Spring 2018 / Fall 2018 / Spring 2019 / Spring 2020
    May be repeated up to 15 total credit hours.
  • MCDB 2150 - Principles of Genetics
    Primary Instructor - Fall 2018 / Fall 2019
    Introduces the behavior of genes and chromosomes in eukaryotic and prokaryotic organisms. Covers three areas: transmission genetics, molecular genetics, and population genetics. Attention is given to genetic mapping, recombinant DNA procedures, and gene expression. Recommended prerequisite: MCDB 1150 or EBIO 1210 or CHEN 2810 (minimum grade C-) and recommended corequisites of MCDB 2151 and MCDB 2152. Degree credit not granted for this course and MCDB 2222.
  • MCDB 4980 - Honors Research
    Primary Instructor - Fall 2019
    Provides faculty-supervised research for students who have been approved by the departmental honors committee. Normally taken during the semester before completion of the honors thesis. Recommended prerequisite: MCDB 4840 or comparable research experience, and minimum GPA of 3.20.
  • MCDB 4990 - Honors Thesis
    Primary Instructor - Fall 2019
    Involves the preparation and defense of an honors thesis, based on faculty-supervised original research, including final phases of the research project. Recommended prerequisites: MCDB 4840 or MCDB 4980 or comparable research experience, and minimum GPA of 3.3 and approval by the MCDB Honors Committee.
  • MCDB 6000 - Introduction to Laboratory Methods
    Primary Instructor - Spring 2018 / Spring 2019 / Spring 2020
    Introduces methodology and techniques used in biological research. Designed as a tutorial between a few students and one faculty member. Students are expected to read original research papers, discuss findings, and to plan and execute experiments in selected areas. Open only to MCDB graduate students. May be repeated up to 9 total credit hours.


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