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Publications in VIVO

Orth, James D Asst Research Professor


Research Areas research areas


research overview

  • Professor Orth studies cancer therapies at the molecular and cellular level. During anti-cancer drug response there is often a disconnect in understanding molecular responses in cells and their fates. This is due to profound heterogeneity within the cancer cell population and tremendous variability in drug response that is difficult to study directly. These characteristics of cancer cells limits our ability to most effectively treat them, and could help explain drug resistance and treatment failure. Quantitative microscopy can add significantly to our understanding of therapeutic action. We relentlessly pursue how to apply advanced microscopy to the problem of cancer and develop single cell assays that allow us to study anti-cancer drug mechanism as it occurs. Through a direct and longitudinal approach, we develop a mechanistic model where we account for the response and fate of every single cell within a population. This powerful approach can be extended to in vivo tumor models.


  • cancer pharmacology, anti-cancer drug action, fractional response to therapy, adaptive drug resistance, anti-mitotic drugs, tumor biology, single-cell drug response, fluorescent microscopy, live-cell microscopy, xenograft tumors, cell culture, cell engineering, small molecule screening, DNA damage, apoptosis, cell stress


selected publications


courses taught

  • MCDB 3150 Biology of the Cancer Cell (Spring 2019)
  • MCDB 6000 Introduction to Laboratory Methods (Spring 2019)
  • MCDB 8990 Doctoral Dissertation (Spring 2019)
  • MCDB 4840 Upper-Division Independent Study (Fall 2018)
  • MCDB 6000 Introduction to Laboratory Methods (Fall 2018)
  • MCDB 8990 Doctoral Dissertation (Fall 2018)
  • MCDB 6000 Introduction to Laboratory Methods (Spring 2018)
  • MCDB 8990 Doctoral Dissertation (Spring 2018)


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