Amino acid specificity in translation. Journal Article uri icon

Overview

abstract

  • Recent structural and biochemical experiments indicate that bacterial elongation factor Tu and the ribosomal A-site show specificity for both the amino acid and the tRNA portions of their aminoacyl-tRNA (aa-tRNA) substrates. These data are inconsistent with the traditional view that tRNAs are generic adaptors in translation. We hypothesize that each tRNA sequence has co-evolved with its cognate amino acid, such that all aa-tRNAs are translated uniformly.

publication date

  • December 1, 2005

Date in CU Experts

  • March 13, 2015 12:56 PM

Full Author List

  • Dale T; Uhlenbeck OC

author count

  • 2

citation count

  • 29

Other Profiles

International Standard Serial Number (ISSN)

  • 0968-0004

Additional Document Info

start page

  • 659

end page

  • 665

volume

  • 30

issue

  • 12