Publications in VIVO

Co-author Network

Uhlenbeck, Olke C

Professor Emerita/Emeritus

Positions

Professor Emerita/Emeritus, Biochemistry

Research Areas

Biochemistry, Nucleic Acid

Publications

selected publications

conference proceeding
- The hammerhead ribozyme. Biochemical Society Transactions. 1119-1122. 2002
- USING IN-VITRO EVOLUTION TO FIND NEW RNA CATALYSIS. 113-126. 1993
- GUANOSINE MODIFICATIONS IN RUNOFF TRANSCRIPTS OF SYNTHETIC TRANSFER RNA-PHE GENES MICROINJECTED INTO XENOPUS OOCYTES. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics. 267-273. 1990
- THE RECOGNITION OF YEAST TRANSFER-RNA BY ITS COGNATE SYNTHETASE. 77-89. 1989
journal article
- In vitro selection of DNAs with an increased propensity to form small circles.. Biopolymers. 303-320. 2015
- Labeled EF-Tus for rapid kinetic studies of pretranslocation complex formation.. ACS Chemical Biology. 2421-2431. 2014
- The interface between Escherichia coli elongation factor Tu and aminoacyl-tRNA.. Biochemistry. 5710-5720. 2014
- Chemical map of Schizosaccharomyces pombe reveals species-specific features in nucleosome positioning.. Proceedings of the National Academy of Sciences of USA. 20158-20163. 2013
- tRNA residues evolved to promote translational accuracy.. RNA. 510-516. 2013
- Duplex destabilization by four ribosomal DEAD-box proteins.. Biochemistry. 10109-10118. 2012
- Histidine 66 in Escherichia coli elongation factor tu selectively stabilizes aminoacyl-tRNAs.. Journal of Biological Chemistry. 1229-1234. 2012
- Is the sequence-specific binding of aminoacyl-tRNAs by EF-Tu universal among bacteria?. Nucleic Acids Research. 9746-9758. 2011
- Functional consequences of T-stem mutations in E. coli tRNAThrUGU in vitro and in vivo.. RNA. 1038-1047. 2011
- Tuning the affinity of aminoacyl-tRNA to elongation factor Tu for optimal decoding.. Proceedings of the National Academy of Sciences of USA. 5215-5220. 2011
- Enhanced product stability in the hammerhead ribozyme.. Biochemistry. 4494-4500. 2010
- A dominant negative mutant of the E. coli RNA helicase DbpA blocks assembly of the 50S ribosomal subunit.. Nucleic Acids Research. 6503-6514. 2009
- RNA biophysics has come of age.. Biopolymers. 811-814. 2009
- A sequence element that tunes Escherichia coli tRNA(Ala)(GGC) to ensure accurate decoding.. Nature Structural and Molecular Biology. 359-364. 2009
- Understanding the sequence specificity of tRNA binding to elongation factor Tu using tRNA mutagenesis.. Journal of Molecular Biology. 1255-1264. 2009
- Specificity of the ribosomal A site for aminoacyl-tRNAs.. Nucleic Acids Research. 1202-1210. 2009
- Differential RNA-dependent ATPase activities of four rRNA processing yeast DEAD-box proteins.. Biochemistry. 12562-12573. 2008
- Different aa-tRNAs are selected uniformly on the ribosome.. Molecular Cell. 114-123. 2008
- Catalytic diversity of extended hammerhead ribozymes.. Biochemistry. 7034-7042. 2008
- Hammerhead redux: does the new structure fit the old biochemical data?. RNA. 605-615. 2008
- [3'-32P]-labeling tRNA with nucleotidyltransferase for assaying aminoacylation and peptide bond formation.. Methods. 74-80. 2008
- Minimal and extended hammerheads utilize a similar dynamic reaction mechanism for catalysis.. RNA. 43-54. 2008
- Mutation of the arginine finger in the active site of Escherichia coli DbpA abolishes ATPase and helicase activity and confers a dominant slow growth phenotype.. Nucleic Acids Research. 41-50. 2008
- The 51-63 base pair of tRNA confers specificity for binding by EF-Tu.. RNA. 835-840. 2007
- Exploring the specificity of bacterial elongation factor Tu for different tRNAs.. Biochemistry. 6194-6200. 2007
- Directed mutagenesis identifies amino acid residues involved in elongation factor Tu binding to yeast Phe-tRNAPhe.. Journal of Molecular Biology. 119-130. 2007
- When to believe what you see.. Molecular Cell. 447-450. 2006
- tRNA residues that have coevolved with their anticodon to ensure uniform and accurate codon recognition.. Biochimie. 943-950. 2006
- The domain of the Bacillus subtilis DEAD-box helicase YxiN that is responsible for specific binding of 23S rRNA has an RNA recognition motif fold.. RNA. 959-967. 2006
- Alanine scanning of MS2 coat protein reveals protein-phosphate contacts involved in thermodynamic hot spots.. Journal of Molecular Biology. 613-624. 2006
- Quantitative analysis of deoxynucleotide substitutions in the codon-anticodon helix.. Journal of Molecular Biology. 887-892. 2006
- Amino acid specificity in translation.. Trends in Biochemical Sciences. 659-665. 2005
- Hammerheads derived from sTRSV show enhanced cleavage and ligation rate constants.. Biochemistry. 14577-14585. 2005
- Binding of misacylated tRNAs to the ribosomal A site.. RNA. 1610-1615. 2005
- YxiN is a modular protein combining a DEx(D/H) core and a specific RNA-binding domain.. Journal of Biological Chemistry. 35499-35505. 2005
- Idiosyncratic tuning of tRNAs to achieve uniform ribosome binding.. Nature Structural and Molecular Biology. 788-793. 2005
- Predicting the binding affinities of misacylated tRNAs for Thermus thermophilus EF-Tu.GTP.. Biochemistry. 11254-11261. 2005
- Escherichia coli DbpA is a 3' --> 5' RNA helicase.. Biochemistry. 7903-7911. 2005
- The structure-function dilemma of the hammerhead ribozyme.. Annual Review of Biophysics. 415-440. 2005
- Uniform binding of aminoacylated transfer RNAs to the ribosomal A and P sites.. Molecular Cell. 799-805. 2004
- Contribution of the esterified amino acid to the binding of aminoacylated tRNAs to the ribosomal P- and A-sites.. Biochemistry. 7575-7583. 2004
- The affinity of elongation factor Tu for an aminoacyl-tRNA is modulated by the esterified amino acid.. Biochemistry. 6159-6166. 2004
- Hasty decisions on the ribosome.. Nature Structural and Molecular Biology. 206-208. 2004
- Interaction of Escherichia coli DbpA with 23S rRNA in different functional states of the enzyme.. Nucleic Acids Research. 3028-3032. 2004
- Less isn't always more.. RNA. 1415-1417. 2003
- The carboxy-terminal domain of the DExD/H protein YxiN is sufficient to confer specificity for 23 S rRNA. Journal of Molecular Biology. 625-636. 2002
- Steric interference modification of the hammerhead ribozyme. Chemistry and Biology. 1009-1016. 2002
- Internal equilibrium of the hammerhead ribozyme is altered by the length of certain covalent cross-links. Biochemistry. 6834-6841. 2002
- Modulation of tRNA^Ala identity by inorganic pyrophosphatase. Proceedings of the National Academy of Sciences of USA. 5965-5970. 2002
- Cooperative binding of ATP and RNA substrates to the DEAD/H protein DbpA. Biochemistry. 3693-3702. 2002
- The tRNA specificity of Thermus thermophilus EF-Tu. Proceedings of the National Academy of Sciences of USA. 3499-3504. 2002
- Modifying the specificity of an RNA backbone contact. Journal of Molecular Biology. 649-654. 2001
- Chemical and enzymatic synthesis of tRNAs for high-throughput crystallization. RNA. 1671-1678. 2001
- Uniform binding of aminoacyl-tRNAs to elongation factor Tu by thermodynamic compensation. Science. 165-168. 2001
- Escherichia coli DbpA is an RNA helicase that requires hairpin 92 of 23S rRNA. The EMBO Journal. 5503-5512. 2001
- A covalent crosslink converts the hammerhead ribozyme from a ribonuclease to an RNA ligase. Nature Structural and Molecular Biology. 863-867. 2001
- Identification of thermodynamically relevant interactions between EF-Tu and backbone elements of tRNA. Journal of Molecular Biology. 895-905. 2001
- The Escherichia coli DEAD protein DbpA recognizes a small RNA hairpin in 23S rRNA. RNA. 702-709. 2001
- Comparison of the hammerhead cleavage reactions stimulated by monovalent and divalent cations. RNA. 537-545. 2001
- Evaluation of methylphosphonates as analogs for detecting phosphate contacts in RNA-protein complexes. RNA. 622-631. 2001
- tRNA conformity. Cold Spring Harbor Laboratory: Symposia on Quantitative Biology. 185-193. 2001
- Interactions of Escherichia coli RNA with bacteriophage MS2 coat protein: genomic SELEX. Nucleic Acids Research. 2000
- RNA aptamers as pathway-specific MAP kinase inhibitors. Chemistry and Biology. 833-843. 2000
- Mapping contacts between Escherichia coli alanyl tRNA synthetase and 2 ' hydroxyls using a complete tRNA molecule. Biochemistry. 8250-8258. 2000
- Hammerhead cleavage of the phosphorodithioate linkage. Biochemistry. 4947-4954. 2000
- Intact aminoacyl-tRNA is required to trigger GTP hydrolysis by elongation factor Tu on the ribosome. Biochemistry. 1734-1738. 2000
- Using phosphorothioate-substituted RNA to investigate the thermodynamic role of phosphates in a sequence specific RNA-protein complex. Biochemistry. 55-63. 2000
- Probing the binding of Tb(III) and Eu(III) to the hammerhead ribozyme using luminescence spectroscopy. Chemistry and Biology. 801-810. 1999
- Cloning and biochemical characterization of Bacillus subtilis YxiN, a DEAD protein specifically activated by 23S rRNA: delineation of a novel sub-family of bacterial DEAD proteins. Nucleic Acids Research. 3811-3820. 1999
- The cleavage properties of modified hammerheads. The FASEB Journal. A1319-A1319. 1999
- A re-investigation of the thio effect at the hammerhead cleavage site. Nucleic Acids Research. 479-484. 1999
- Quantitative assessment of EF-1α•GTP binding to aminoacyl-tRNAs, aminoacyl-viral RNA, and tRNA shows close correspondence to the RNA binding properties of EF-Tu. Journal of Biological Chemistry. 666-672. 1999
- Kinetic analysis of the RNA-dependent adenosinetriphosphatase activity of DbpA, an Escherichia coli DEAD protein specific for 23S ribosomal RNA. Biochemistry. 16989-16996. 1998
- Thermodynamic dissection of the substrate-ribozyme interaction in the hammerhead ribozyme. Biochemistry. 16983-16988. 1998
- Cryoenzymology of the hammerhead ribozyme. RNA. 1251-1258. 1998
- T7 RNA polymerase produces 5′ end heterogeneity during in vitro transcription from certain templates. RNA. 1313-1317. 1998
- A thermodynamic analysis of the sequence-specific binding of RNA by bacteriophage MS2 coat protein. Proceedings of the National Academy of Sciences of USA. 9244-9249. 1998
- A new assay for tRNA aminoacylation kinetics. RNA. 1019-1023. 1998
- Hammerhead ribozyme kinetics. RNA. 875-889. 1998
- Circular substrates of the hammerhead ribozyme shift the internal equilibrium further toward cleavage. Biochemistry. 9386-9393. 1998
- Structural variation induced by different nucleotides at the cleavage site of the hammerhead ribozyme. Biochemistry. 4034-4044. 1998
- A coat for all sequences. Nature Structural and Molecular Biology. 174-176. 1998
- Inhibition of the hammerhead ribozyme cleavage reaction by site-specific binding of Tb(III). Science. 81-84. 1998
- Involvement of a specific metal ion in the transition of the hammerhead ribozyme to its catalytic conformation. Journal of Biological Chemistry. 26822-26826. 1997
- Functional groups on the cleavage site pyrimidine nucleotide are required for stabilization of the hammerhead transition state. RNA. 1135-1142. 1997
- RNA structure comes of age. Cell. 833-840. 1997
- Use of intrinsic binding energy for catalysis by an RNA enzyme. Proceedings of the National Academy of Sciences of USA. 8497-8502. 1997
- The hammerhead ribozyme.. The FASEB Journal. A852-A852. 1997
- Hammerhead ribozymes with a faster cleavage rate. Biochemistry. 9087-9092. 1997
- A kinetic and thermodynamic analysis of cleavage site mutations in the hammerhead ribozyme. Biochemistry. 1108-1114. 1997
- RNA recognition by the MS2 phage coat protein. Seminars in virology. 176-185. 1997
- Mutagenesis of a stacking contact in the MS2 coat protein-RNA complex. The EMBO Journal. 6847-6853. 1996
- Probing the role of metal ions in the hammerhead ribozyme cleavage reaction.. ACS National Meeting Book of Abstracts. 203-INOR. 1996
- Specificity of hammerhead ribozyme cleavage. The EMBO Journal. 3751-3757. 1996
- Kinetic characterization of two I/II format hammerhead ribozymes. RNA. 483-491. 1996
- DIVALENT METAL-IONS AND THE INTERNAL EQUILIBRIUM OF THE HAMMERHEAD RIBOZYME. Biochemistry. 14435-14440. 1995
- THE ROLE OF 2'-HYDROXYL GROUPS IN AN RNA-PROTEIN INTERACTION. Biochemistry. 12363-12368. 1995
- NEOMYCIN INHIBITION OF THE HAMMERHEAD RIBOZYME INVOLVES IONIC INTERACTIONS. Biochemistry. 11186-11190. 1995
- MUTANTS OF THE BACTERIOPHAGE-MS2 COAT PROTEIN THAT ALTER ITS COOPERATIVE BINDING TO RNA. Biochemistry. 10600-10606. 1995
- HAMMERHEAD .2.. Nature Structural and Molecular Biology. 610-614. 1995
- Hammerhead: Part 2.. Nature Structural and Molecular Biology. 610-614. 1995
- THE EFFECT OF BASE MISMATCHES IN THE SUBSTRATE RECOGNITION HELICES OF HAMMERHEAD RIBOZYMES ON BINDING AND CATALYSIS. Nucleic Acids Research. 2092-2096. 1995
- PROTON NMR AND STRUCTURAL FEATURES OF A 24-NUCLEOTIDE RNA HAIRPIN. Biochemistry. 6488-6503. 1995
- INHIBITION OF THE HAMMERHEAD RIBOZYME BY NEOMYCIN. RNA. 95-101. 1995
- KEEPING RNA HAPPY. RNA. 4-6. 1995
- DEFINING A SMALLER RNA SUBSTRATE FOR ELONGATION-FACTOR TU. Biochemistry. 2545-2552. 1995
- THE INTERNAL EQUILIBRIUM OF THE HAMMERHEAD RIBOZYME REACTION. Biochemistry. 1744-1749. 1995
- DIVALENT CADMIUM RESTORES CATALYSIS OF A THIOPHOSPHATE-SUBSTITUTED HAMMERHEAD RIBOZYME. Journal of Cellular Biochemistry. 217-217. 1995
- AN RNA-PROTEIN CONTACT DETERMINED BY 5-BROMOURIDINE SUBSTITUTION, PHOTO-CROSS-LINKING AND SEQUENCING. Nucleic Acids Research. 4947-4952. 1994
- RIBOZYMES - HAMMERHEAD NAILED DOWN. Nature. 39-40. 1994
- IN-VITRO SELECTION OF SMALL RNAS THAT BIND TO ESCHERICHIA-COLI PHENYLALANYL-TRANSFER-RNA SYNTHETASE. Journal of Molecular Biology. 186-192. 1994
- PROPERTIES OF AN IN-VITRO SELECTED PB2+ CLEAVAGE MOTIF. Biochemistry. 9561-9565. 1994
- KINETIC CHARACTERIZATION OF INTRAMOLECULAR AND INTERMOLECULAR HAMMERHEAD RNAS WITH STEM-II DELETIONS. Proceedings of the National Academy of Sciences of USA. 6977-6981. 1994
- RNA TEMPLATE-DIRECTED RNA-SYNTHESIS BY T7 RNA-POLYMERASE. Proceedings of the National Academy of Sciences of USA. 6972-6976. 1994
- MANY OF THE CONSERVED NUCLEOTIDES OF TRNA(PHE) ARE NOT ESSENTIAL FOR TERNARY COMPLEX-FORMATION AND PEPTIDE ELONGATION. The EMBO Journal. 2464-2471. 1994
- A KINETIC AND THERMODYNAMIC FRAMEWORK FOR THE HAMMERHEAD RIBOZYME REACTION. Biochemistry. 3374-3385. 1994
- USING CIRCULAR PERMUTATION ANALYSIS TO REDEFINE THE R17 COAT PROTEIN-BINDING SITE. Biochemistry. 13399-13404. 1993
- EVIDENCE FOR THE ROLE OF SOLVATED METAL HYDROXIDE IN THE HAMMERHEAD CLEAVAGE MECHANISM. Biochemistry. 13040-13045. 1993
- PHOTO-CROSS-LINKING OF 5-IODOURACIL SUBSTITUTED RNA AND DNA TO PROTEINS. Science. 1255-1257. 1993
- IN-VITRO ANALYSIS OF TRANSLATIONAL RATE AND ACCURACY WITH AN UNMODIFIED TRANSFER-RNA. Biochemistry. 7617-7622. 1993
- SELECTION FOR ACTIVE ESCHERICHIA-COLI TRANSFER RNA(PHE) VARIANTS FROM A RANDOMIZED LIBRARY USING 2 PROTEINS. The EMBO Journal. 2959-2967. 1993
- CIRCULARLY PERMUTED DNA, RNA AND PROTEINS - A REVIEW. Gene. 111-114. 1993
- HIGH-YIELD PHOTO-CROSS-LINKING BETWEEN 5-HALOURACIL SUBSTITUTED NUCLEIC-ACIDS AND ASSOCIATED PROTEINS. ACS National Meeting Book of Abstracts. 11-ORGN. 1993
- REPLACEMENT OF RNA HAIRPINS BY INVITRO SELECTED TETRANUCLEOTIDES. Nucleic Acids Research. 531-535. 1993
- SELF-CLEAVING CATALYTIC RNA. The FASEB Journal. 25-30. 1993
- THE MECHANISM OF THE HAMMERHEAD RIBOZYME. Protein Engineering Design and Selection. 38-38. 1993
- KINETICS OF INTERMOLECULAR CLEAVAGE BY HAMMERHEAD RIBOZYMES. Biochemistry. 12042-12054. 1992
- DETERMINATION OF RECOGNITION NUCLEOTIDES FOR ESCHERICHIA-COLI PHENYLALANYL-TRANSFER RNA-SYNTHETASE. Biochemistry. 10380-10389. 1992
- A SMALL METALLORIBOZYME WITH A 2-STEP MECHANISM. Nature. 560-563. 1992
- AN ULTRAVIOLET LIGHT-INDUCED CROSS-LINK IN YEAST TRANSFER RNAPHE. Nucleic Acids Research. 4055-4059. 1992
- NUMBERING SYSTEM FOR THE HAMMERHEAD. Nucleic Acids Research. 3252-3252. 1992
- RECOGNITION OF YEAST TRANSFER RNA(PHE) BY ITS COGNATE YEAST PHENYLALANYL-TRANSFER RNA-SYNTHETASE - AN ANALYSIS OF SPECIFICITY. Biochemistry. 4161-4167. 1992
- INVITRO SELECTION OF RNAS THAT UNDERGO AUTOLYTIC CLEAVAGE WITH PB2+. Biochemistry. 3887-3895. 1992
- In vitro selection of RNAs that undergo autolytic cleavage with Pb2+.. Biochemistry. 3887-3895. 1992
- RECOGNITION NUCLEOTIDES FOR HUMAN PHENYLALANYL-TRANSFER RNA-SYNTHETASE. Nucleic Acids Research. 475-478. 1992
- RECOGNITION OF TERTIARY STRUCTURE IN TRANSFER-RNAS BY RH(PHEN)2PHI3+, A NEW REAGENT FOR RNA STRUCTURE-FUNCTION MAPPING. Biochemistry. 972-982. 1992
- INVITRO SELECTION OF RNAS THAT CATALYZE SELF-CLEAVAGE REACTIONS WITH PB2+. The FASEB Journal. A412-A412. 1992
- SUBSTRATE DESTABILIZATION BY THE HAMMERHEAD RIBOZYME. The FASEB Journal. A411-A411. 1992
- RNA-BINDING PROPERTIES OF THE COAT PROTEIN FROM BACTERIOPHAGE GA. Nucleic Acids Research. 6499-6503. 1991
- FOLDING OF CIRCULARLY PERMUTED TRANSFER-RNAS. Science. 1361-1364. 1991
- ROLE OF DIVALENT METAL-IONS IN THE HAMMERHEAD RNA CLEAVAGE REACTION. Biochemistry. 9464-9469. 1991
- A SPECIFIC, UV-INDUCED RNA PROTEIN CROSS-LINK USING 5-BROMOURIDINE-SUBSTITUTED RNA. Biochemistry. 6290-6295. 1991
- SPECIFIC INTERACTION BETWEEN RNA PHAGE COAT PROTEINS AND RNA. Progress in Molecular Biology and Translational Science. 185-220. 1991
- COOPERATIVE BINDING OF R17 COAT PROTEIN TO RNA. Biochemistry. 11051-11057. 1990
- SEQUENCE REQUIREMENTS OF THE HAMMERHEAD RNA SELF-CLEAVAGE REACTION. Biochemistry. 10695-10702. 1990
- THE SELF-SPLICING RNA OF TETRAHYMENA IS TRAPPED IN A LESS ACTIVE CONFORMATION BY GEL PURIFICATION. Biochemistry. 10573-10576. 1990
- CHARACTERIZATION OF DEOXY-CONTAINING AND RIBO-CONTAINING OLIGONUCLEOTIDE SUBSTRATES IN THE HAMMERHEAD SELF-CLEAVAGE REACTION. Biochimie. 819-823. 1990
- THIOPHOSPHATE INTERFERENCE EXPERIMENTS LOCATE PHOSPHATES IMPORTANT FOR THE HAMMERHEAD RNA SELF-CLEAVAGE REACTION. Nucleic Acids Research. 6025-6029. 1990
- NUCLEIC-ACID STRUCTURE - TETRALOOPS AND RNA FOLDING. Nature. 613-614. 1990
- LEAD-CATALYZED CLEAVAGE OF YEAST TRANSFER RNAPHE MUTANTS. Biochemistry. 2515-2523. 1990
- ROLE OF THE TERTIARY NUCLEOTIDES IN THE INTERACTION OF YEAST PHENYLALANINE TRANSFER-RNA WITH ITS COGNATE SYNTHETASE. Biochemistry. 2523-2532. 1990
- SEQUENCE-DEPENDENT STRUCTURAL VARIATIONS OF HAMMERHEAD RNA ENZYMES. Nucleic Acids Research. 1103-1108. 1990
- SUBSTRATE SEQUENCE EFFECTS ON HAMMERHEAD RNA CATALYTIC EFFICIENCY. Proceedings of the National Academy of Sciences of USA. 1668-1672. 1990
- STUDIES ON THE HAMMERHEAD RNA SELF-CLEAVING DOMAIN. Gene. 31-41. 1989
- STRUCTURE OF AN UNMODIFIED TRANSFER-RNA MOLECULE. Biochemistry. 5794-5801. 1989
- DETERMINATION OF RNA PROTEIN CONTACTS USING THIOPHOSPHATE SUBSTITUTIONS. Biochemistry. 2849-2855. 1989
- NUCLEOTIDES IN YEAST TRANSFER RNAPHE REQUIRED FOR THE SPECIFIC RECOGNITION BY ITS COGNATE SYNTHETASE. Science. 1363-1366. 1989
- THERMAL-STABILITY OF RNA HAIRPINS CONTAINING A 4-MEMBERED LOOP AND A BULGE NUCLEOTIDE. Biochemistry. 742-747. 1989
- SPECIFIC RNA-BINDING BY Q-BETA COAT PROTEIN. Biochemistry. 71-76. 1989
- SYNTHESIS OF SMALL RNAS USING T7 RNA-POLYMERASE. Methods in Enzymology. 51-62. 1989
- Structure and mechanism of the hammerhead self-cleaving domain.. Nucleic Acids Symposium Series. 95-96. 1989
- CHARACTERIZATION OF RNA HAIRPIN LOOP STABILITY. Nucleic Acids Research. 11725-11735. 1988
- RIBONUCLEOPROTEIN COMPLEXES OF R17 COAT PROTEIN AND A TRANSLATIONAL OPERATOR ANALOG. Journal of Molecular Biology. 927-938. 1988
- ROLES OF OPERATOR AND NON-OPERATOR RNA SEQUENCES IN BACTERIOPHAGE R17 CAPSID ASSEMBLY. Journal of Molecular Biology. 939-947. 1988
- A COMPARISON OF 2 PHAGE COAT PROTEIN RNA INTERACTIONS. Nucleic Acids Research. 5055-5066. 1988
- CUUCGG HAIRPINS - EXTRAORDINARILY STABLE RNA SECONDARY STRUCTURES ASSOCIATED WITH VARIOUS BIOCHEMICAL PROCESSES. Proceedings of the National Academy of Sciences of USA. 1364-1368. 1988
- BIOCHEMICAL AND PHYSICAL CHARACTERIZATION OF AN UNMODIFIED YEAST PHENYLALANINE TRANSFER-RNA TRANSCRIBED INVITRO. Proceedings of the National Academy of Sciences of USA. 1033-1037. 1988
- AN RNA MUTATION THAT INCREASES THE AFFINITY OF AN RNA PROTEIN-INTERACTION. Nucleic Acids Research. 10483-10493. 1987
- ROLE OF A BULGED-A RESIDUE IN A SPECIFIC RNA PROTEIN-INTERACTION. Biochemistry. 8221-8227. 1987
- OLIGORIBONUCLEOTIDE SYNTHESIS USING T7 RNA-POLYMERASE AND SYNTHETIC DNA TEMPLATES. Nucleic Acids Research. 8783-8798. 1987
- A SMALL CATALYTIC OLIGORIBONUCLEOTIDE. Nature. 596-600. 1987
- RNA-BINDING SITE OF R17 COAT PROTEIN. Biochemistry. 1563-1568. 1987
- CHARACTERIZATION OF 2 RNA-CATALYZED RNA CLEAVAGE REACTIONS. Cold Spring Harbor Laboratory: Symposia on Quantitative Biology. 267-275. 1987
- SPECIFIC SUBSTITUTION INTO THE ANTICODON LOOP OF YEAST TYROSINE TRANSFER-RNA. Biochemistry. 5825-5830. 1986
- STRUCTURE AND FUNCTION OF RNA. Chemica scripta. 97-101. 1986
- EFFECT OF REPLACING URIDINE-33 IN YEAST TRANSFER RNAPHE ON THE REACTION WITH RIBOSOMES. Journal of Biological Chemistry. 112-118. 1986
- Effect of replacing uridine 33 in yeast tRNAPhe on the reaction with ribosomes.. Journal of Biological Chemistry. 10112-10118. 1986
- Nucleoside and nucleotide inactivation of R17 coat protein: evidence for a transient covalent RNA-protein bond.. Biochemistry. 4239-4244. 1985
- Specific replacement of functional groups of uridine-33 in yeast phenylalanine transfer ribonucleic acid.. Biochemistry. 2705-2712. 1985
- Aminoacylation of anticodon loop substituted yeast tyrosine transfer RNA.. Biochemistry. 2354-2360. 1985
- Chromosomal sites of integration of simian virus 40 DNA sequences mapped by in situ hybridization in two transformed hybrid cell lines.. Journal of Virology. 445-451. 1984
- Failure of translational repression in the phage f2 op3 mutant is not due to an altered coat protein-RNA interaction.. Journal of Biological Chemistry. 20-22. 1984
- Uridine-33 in yeast tRNA not essential for amber suppression.. Nature. 554-556. 1983
- Interaction of R17 coat protein with its RNA binding site for translational repression.. Journal of Biomolecular Structure and Dynamics. 539-552. 1983
- Interaction of R17 coat protein with synthetic variants of its ribonucleic acid binding site.. Biochemistry. 4723-4730. 1983
- Binding of yeast tRNAPhe anticodon arm to Escherichia coli 30 S ribosomes.. Journal of Molecular Biology. 103-117. 1983
- Kinetic and thermodynamic characterization of the R17 coat protein-ribonucleic acid interaction.. Biochemistry. 2610-2615. 1983
- Sequence-specific interaction of R17 coat protein with its ribonucleic acid binding site.. Biochemistry. 2601-2610. 1983
- Joining of RNA molecules with RNA ligase.. Methods in Enzymology. 52-59. 1983
- Independent locations of kinase and 3'-phosphatase activities on T4 polynucleotide kinase.. Journal of Biological Chemistry. 11340-11345. 1982
- Isolation and characterization of two mutant forms of T4 polynucleotide kinase.. Journal of Biological Chemistry. 11332-11339. 1982
- Enzymatic synthesis of a 21-nucleotide coat protein binding fragment of R17 ribonucleic acid.. Biochemistry. 4713-4720. 1982
- Specific interaction of anticodon loop residues with yeast phenylalanyl-tRNA synthetase.. Biochemistry. 3921-3926. 1982
- Role of the constant uridine in binding of yeast tRNAPhe anticodon arm to 30S ribosomes.. Nucleic Acids Research. 3341-3352. 1982
- Reversal of T4 RNA ligase.. Biochemistry. 1858-1864. 1982
- Enzymatic replacement of the anticodon of yeast phenylalanine transfer ribonucleic acid.. Biochemistry. 855-861. 1982
- T4 RNA ligase as a nucleic acid synthesis and modification reagent.. Gene amplification and analysis. 313-345. 1981
- Interaction of Escherichia coli host factor protein with Q beta ribonucleic acid.. Biochemistry. 6146-6151. 1980
- Interaction of Escherichia coli host factor protein with oligoriboadenylates.. Biochemistry. 6138-6146. 1980
- In situ hybridization of three transfer RNAs to the polytene chromosomes of Drosophila melanogaster.. Journal of Molecular Biology. 1-17. 1980
- Quantitation of in situ hybridization of ribosomal ribonucleic acids to human diploid cells.. Chromosoma: biology of the nucleus. 349-367. 1980
- Specific labeling of 3' termini of RNA with T4 RNA ligase.. Methods in Enzymology. 65-74. 1980
- 3'-terminal labelling of RNA with T4 RNA ligase.. Nature. 560-561. 1978
- Reactions at the termini of tRNA with T4 RNA ligase.. Nucleic Acids Research. 3665-3677. 1978
- Use of T4 RNA ligase to construct model substrates for a ribosomal RNA maturation endonuclease.. Proceedings of the National Academy of Sciences of USA. 3045-3049. 1978
- Enzymatic oligoribonucleotide synthesis with T4 RNA ligase.. Biochemistry. 2069-2076. 1978
- Synthesis of modified nucleoside 3',5'-bisphosphates and their incorporation into oligoribonucleotides with T4 RNA ligase.. Biochemistry. 2077-2081. 1978
- Polynucleotide kinase from a T4 mutant which lacks the 3' phosphatase activity.. Nucleic Acids Research. 825-833. 1978
- 3'-Phosphatase activity in T4 polynucleotide kinase.. Biochemistry. 5120-5126. 1977
- Dinucleoside pyrophosphate are substrates for T4-induced RNA ligase.. Proceedings of the National Academy of Sciences of USA. 4839-4842. 1977
- Quantitative in situ hybridization of ribosomal RNA species to polytene chromosomes of Drosophila melanogaster.. Journal of Molecular Biology. 539-563. 1977
- Equimolar addition of oligoribonucleotides with T4 RNA ligase.. Nucleic Acids Research. 85-98. 1977
- Stepwise enzymatic oligoribonucleotide synthesis including modified nucleotides.. Biochemistry. 817-824. 1975
- T4-induced RNA ligase joins single-stranded oligoribonucleotides.. Proceedings of the National Academy of Sciences of USA. 122-126. 1975
- PMR or the self-complementary oligoribonucleotide CpCpGpG.. Biochemical and Biophysical Research Communications. 1089-1094. 1974
- Oligonucleotide binding to the native and denatured conformers of yeast transfer RNA-3 Lea.. Journal of Molecular Biology. 495-504. 1974
- Stability of ribonucleic acid double-stranded helices.. Journal of Molecular Biology. 843-853. 1974
- Circular dichroism of double-helical oligoribonucleotides.. Journal of Molecular Biology. 759-771. 1973
- Improved estimation of secondary structure in ribonucleic acids.. Nature. 40-41. 1973
- Removal of Y-37 from tRNA phe yeast alters oligomer binding to two loops.. Biochemical and Biophysical Research Communications. 635-640. 1973
- Stability of RNA hairpin loops: A 6 -C m -U 6 .. Journal of Molecular Biology. 483-496. 1973
- Circular dichroism study of nine species of transfer ribonucleic acid.. Biochemistry. 3248-3256. 1972
- Complementary oligonucleotide binding to transfer RNA.. Journal of Molecular Biology. 25-41. 1972
- Binding of complementary oligonucleotides to free and aminoacyl transfer ribonucleic acid synthetase bound transfer ribonucleic acid.. Biochemistry. 642-646. 1972
- Self-complementary oligoribonucleotides: adenylic acid-uridylic acid block copolymers.. Journal of Molecular Biology. 201-215. 1971
- Self-complementary oligoribonucleotides: effects of helix defects and guanylic acid-cytidylic acid base pairs.. Journal of Molecular Biology. 217-229. 1971
- Estimation of secondary structure in ribonucleic acids.. Nature. 362-367. 1971
- Complementary oligonucleotide binding to the anticodon loop of fMet-transfer RNA.. Nature. 508-510. 1970

Background

education and training

Ph.D., Harvard University 1969

awards and honors

Fellows, conferred by American Academy of Arts and Sciences, 1993