Allosteric drugs: thinking outside the active-site box. Journal Article uri icon

Overview

abstract

  • Recently, a class of small molecules that thermally stabilize the tumor suppressor p53 was selected from a small-molecule library. This, and other recent work, demonstrates the feasibility of taking a lead from nature and selecting new classes of drugs that function by allosteric mechanisms.

publication date

  • May 1, 2000

Full Author List

  • DeDecker BS

Additional Document Info

start page

  • R103

end page

  • R107

volume

  • 7

issue

  • 5