Allosteric drugs: thinking outside the active-site box. Journal Article uri icon



  • Recently, a class of small molecules that thermally stabilize the tumor suppressor p53 was selected from a small-molecule library. This, and other recent work, demonstrates the feasibility of taking a lead from nature and selecting new classes of drugs that function by allosteric mechanisms.

publication date

  • May 1, 2000

Full Author List

  • DeDecker BS

Other Profiles

Additional Document Info

start page

  • R103

end page

  • R107


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  • 5