The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure. Journal Article uri icon

Overview

abstract

  • Histone methylation regulates chromatin function dependent on the site and degree of the modification. In addition to creating binding sites for proteins, methylated lysine residues are likely to influence chromatin structure directly. Here we present crystal structures of nucleosomes reconstituted with methylated histones and investigate the folding behavior of resulting arrays. We demonstrate that dimethylation of histone H3 at lysine residue 79 locally alters the nucleosomal surface, whereas trimethylation of H4 at lysine residue 20 affects higher-order structure.

publication date

  • October 1, 2008

Full Author List

  • Lu X; Simon MD; Chodaparambil JV; Hansen JC; Shokat KM; Luger K

Other Profiles

Additional Document Info

start page

  • 1122

end page

  • 1124

volume

  • 15

issue

  • 10