Mediator and post-recruitment regulation of RNA polymerase II. Journal Article

Overview

abstract

• The human Mediator complex interacts extensively with the RNA polymerase II (Pol II) enzyme and recent data from our lab suggest activator-induced structural shifts within Mediator trigger activation of stalled Pol II. These results are discussed together with other recent findings regarding post-recruitment regulation of Pol II.

CU Boulder Authors

• Taatjes, Dylan J

publication date

• January 1, 2011

has subject area

• Biochemical Phenomena - Promoter Regions, Genetic
• Biochemical Phenomena - Protein Binding
• Biochemical Phenomena - Transcription, Genetic
• Carrier Proteins - Mediator Complex
• Carrier Proteins - Mediator Complex Subunit 1
• Carrier Proteins - Mediator Complex Subunit 1
• DNA-Binding Proteins - Trans-Activators
• DNA-Binding Proteins - Tumor Suppressor Protein p53
• Gene Expression - Transcription, Genetic
• Genetic Structures - Promoter Regions, Genetic
• Humans
• Metabolism - Protein Binding
• Models, Genetic
• Multiprotein Complexes - Mediator Complex
• Multiprotein Complexes - Mediator Complex Subunit 1
• Mutation
• Nuclear Proteins - Mediator Complex
• Nuclear Proteins - Mediator Complex Subunit 1
• Nuclear Proteins - Mediator Complex Subunit 1
• Nuclear Proteins - Tumor Suppressor Protein p53
• Peptides - Mediator Complex
• Peptides - Mediator Complex Subunit 1
• Peptides - Mediator Complex Subunit 1
• Phosphoproteins - Tumor Suppressor Protein p53
• Protein Conformation
• Protein Subunits
• Proteins - Mediator Complex
• Proteins - Mediator Complex Subunit 1
• Proteins - Mediator Complex Subunit 1
• RNA Polymerase II
• Regulatory Elements, Transcriptional - Promoter Regions, Genetic
• Transcription Factors - Mediator Complex Subunit 1
• Transcription Factors - Trans-Activators
• Tumor Suppressor Proteins - Tumor Suppressor Protein p53
• Viral Regulatory and Accessory Proteins - Trans-Activators

Date in CU Experts

• September 3, 2013 2:59 AM

Full Author List

• Knuesel MT; Taatjes DJ

author count

• 2

citation count

• 7

published in

• Transcription  Journal

Other Profiles

International Standard Serial Number (ISSN)

• 2154-1264

Electronic International Standard Serial Number (EISSN)

• 2154-1272

Digital Object Identifier (DOI)

• 10.4161/trns.2.1.13950

Additional Document Info

start page

• 28

end page

• 31

volume

• 2

issue

• 1