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Taatjes, Dylan J Professor

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Research Areas research areas

Research

research overview

  • The Mediator complex is a multi-subunit assembly required for regulating expression of most RNA polymerase II (pol II) transcripts, which include protein-coding and most non-coding RNA genes. Mediator is generally targeted by sequence-specific, DNA-binding transcription factors (TFs) that control gene expression programs in response to developmental or environmental cues. Mediator functions by relaying signals from TFs directly to the pol II enzyme. Thus, Mediator is essential for converting biological inputs (communicated by TFs) to physiological responses (via changes in gene expression). The Taatjes lab examines the basic mechanisms that underlie Mediator function, with the goal of identifying key molecular interfaces (and/or molecular probes to target these interfaces) that contribute to its broad regulatory influence on gene expression. We are also actively studying factors that influence Mediator structure and activity, including TFs, non-coding RNAs, and the CDK8 module.

keywords

  • Transcription, structural biology, biophysics, cryo-electron microscopy, mass spectrometry, biochemistry and molecular biology, aging, signaling, metabolism

Publications

selected publications

Teaching

courses taught

  • CHEM 4400 Core Concepts in Physical Chemistry for Biochemists (Spring 2019)
  • CHEM 4901 Independent Study in Chemistry and Biochemistry (Spring 2019)
  • CHEM 5400 Core Concepts in Physical Chemistry for Biochemists (Spring 2019)
  • CHEM 6901 Research in Chemistry (Spring 2019)
  • CHEM 8991 Doctoral Dissertation (Spring 2019)
  • CHEM 4901 Independent Study in Chemistry and Biochemistry (Fall 2018)
  • CHEM 6901 Research in Chemistry (Fall 2018)
  • CHEM 8991 Doctoral Dissertation (Fall 2018)
  • CHEM 4901 Independent Study in Chemistry and Biochemistry (Summer 2018)
  • CHEM 6901 Research in Chemistry (Summer 2018)
  • CHEM 8991 Doctoral Dissertation (Summer 2018)
  • CHEM 4901 Independent Study in Chemistry and Biochemistry (Spring 2018)
  • CHEM 5780 Fundamentals of Biochemistry II (Spring 2018)
  • CHEM 5781 Advanced General Biochemistry 2 (Spring 2018)
  • CHEM 6901 Research in Chemistry (Spring 2018)
  • CHEM 8991 Doctoral Dissertation (Spring 2018)

Background

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