Loss of MeCP2 in adult 5-HT neurons induces 5-HT1A autoreceptors, with opposite sex-dependent anxiety and depression phenotypes
Journal Article
Overview
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Animal Population Groups - Mice, Knockout
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Animals
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Anxiety
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Biochemical Phenomena - Promoter Regions, Genetic
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Brain
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Cell Line
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Cell Line, Transformed - HEK293 Cells
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Cells - Serotonergic Neurons
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DNA-Binding Proteins
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DNA-Binding Proteins - Methyl-CpG-Binding Protein 2
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Depression
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Environment and Public Health - Sex Factors
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Epithelial Cells - HEK293 Cells
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Female
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Gene Expression Regulation
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Genetic Structures - Promoter Regions, Genetic
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Health Care Quality, Access, and Evaluation - Sex Factors
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Humans
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Male
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Mice
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Mice - Mice, Knockout
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Mice, Mutant Strains - Mice, Knockout
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Nervous System - Serotonergic Neurons
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Nuclear Proteins
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Nuclear Proteins - Methyl-CpG-Binding Protein 2
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Nucleoproteins - Methyl-CpG-Binding Protein 2
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Receptors, Biogenic Amine - Receptor, Serotonin, 5-HT1A
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Receptors, G-Protein-Coupled - Receptor, Serotonin, 5-HT1A
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Receptors, Neurotransmitter - Receptor, Serotonin, 5-HT1A
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Regulatory Elements, Transcriptional - Promoter Regions, Genetic
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Transcription Factors
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Date in CU Experts
Full Author List
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Philippe TJ; Vahid-Ansari F; Donaldson ZR; Le Francois B; Zahrai A; Turcotte-Cardin V; Daigle M; James J; Hen R; Merali Z
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