Fundamental studies of biodegradable hydrogels as cartilage replacement materials. Journal Article uri icon



  • Through intelligent control of monomer chemistry and gelling techniques, biodegradable hydrogels with a range of mechanical strengths and degradation timescales have been constructed. A diacrylated, copoly(ethylene glycol-b-dl-lactic acid) (PEG-b-PLA) macromer was used to produce synthetic networks with equilibrium water contents (EWC) above 70% and initial compressive moduli values exceeding 1 MPa, demonstrating its viability as a cartilage replacement material. Experiments have shown that the mechanical strengths, EWCs, and useful lifetimes of these water-swellable networks are coupled to their copolymer chemistry as well as their processing conditions. A systematic study utilizing photopolymerized gels has been undertaken to elucidate the controlling factors behind the bulk-degradation process, as well as monitor changes in network structure with degradation. A statistical model will be used in conjunction with the experimental data to explain the exponential modulus decay and complex mass loss behavior observed during degradation for these hydrogels.

publication date

  • January 1, 1999

has subject area

Date in CU Experts

  • September 6, 2013 11:56 AM

Full Author List

  • Metters AT; Anseth KS; Bowman CN

author count

  • 3

Other Profiles

International Standard Serial Number (ISSN)

  • 0067-8856

Additional Document Info

start page

  • 33

end page

  • 38


  • 35