Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity
Journal Article
Overview
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has subject area
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Animal Diseases - Disease Models, Animal
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Animals
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Animals, Inbred Strains - Mice, Inbred C57BL
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Biochemical Phenomena - Repetitive Sequences, Nucleic Acid
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Brain
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Cell Line, Transformed - HEK293 Cells
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Cell Membrane Structures - Nuclear Lamina
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Cell Nucleus Structures - Nuclear Lamina
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Dipeptides
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Epithelial Cells - HEK293 Cells
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Genetic Structures - Heterochromatin
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Genetic Structures - RNA, Double-Stranded
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Genetic Structures - Repetitive Sequences, Nucleic Acid
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Green Fluorescent Proteins
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Humans
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Intranuclear Space - Heterochromatin
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Mice
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Mice - Mice, Inbred C57BL
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Models, Animal - Disease Models, Animal
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Models, Biological - Disease Models, Animal
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Molecular Conformation - RNA, Double-Stranded
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Neurodegenerative Diseases - Amyotrophic Lateral Sclerosis
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Neurodegenerative Diseases - Amyotrophic Lateral Sclerosis
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Neuromuscular Diseases - Amyotrophic Lateral Sclerosis
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Nuclear Matrix - Nuclear Lamina
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Nuclear Proteins - Chromosomal Proteins, Non-Histone
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Nucleoproteins - Chromosomal Proteins, Non-Histone
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Nucleoproteins - Heterochromatin
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Proteostasis Deficiencies - Amyotrophic Lateral Sclerosis
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RNA - RNA, Double-Stranded
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Spinal Cord Diseases - Amyotrophic Lateral Sclerosis
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Subcellular Fractions - Nuclear Lamina
Date in CU Experts
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February 20, 2019 9:13 AM
Full Author List
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Zhang Y-J; Guo L; Gonzales PK; Gendron TF; Wu Y; Jansen-West K; O'Raw AD; Pickles SR; Prudencio M; Carlomagno Y
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