The long-term goal of our research is to understand the cellular and molecular basis of age-associated neurodegenerative diseases, such as Alzheimer's disease (AD) and Amyotrophic Lateral Sclerosis (ALS). The major focus of our studies has been the identification of the cellular and molecular mechanisms by which specific proteins central to these diseases (e.g., the beta amyloid peptide in AD and TDP-43 in ALS) induce pathology. Our primary approach has been to develop transgenic C. elegans strains that express these human proteins, often resulting in abnormal phenotypes that can be the basis of classic genetic screens. The overall rationale for this approach is that invertebrate models allow facile 'pilot' studies that are time-consuming, difficult, or impossible in other systems. We complement the C. elegans studies using mammalian cell culture and bioinformatic analysis of mouse and human deep sequencing data.
modeling human neurodegenerative diseases using cellular and C. elegans models
IPHY 3060 - Cell Physiology
Lect. and lab. Introduces the biology of eukaryotic systems at molecular, cellular and systems levels of integration, emphasizing the complementarities of structure and function and physiological mechanisms of regulation at the cellular and molecular level. Department enforced prerequisite: one year of general biology (lecture + lab). Formerly IPHY 3060.
IPHY 4870 - Honors Thesis
Spring 2018 / Spring 2019 / Spring 2020
Department enforced prerequisites: IPHY 2800 and IPHY 3700.
IPHY 4930 - Internship
Spring 2018 / Summer 2018 / Spring 2019 / Summer 2019
Provides an opportunity for field/laboratory work in a variety of different settings. Consult with faculty for approval. May be repeated up to 6 total credit hours. Department enforced prerequisite: completion of at least two of the major core classes.
IPHY 6840 - Research Project
Spring 2018 / Summer 2018 / Fall 2018 / Spring 2019 / Summer 2019 / Fall 2019 / Spring 2020
Involves a scholarly investigation of a selected topic using literature and/or experimental techniques. Advisor required. May be repeated up to 3 total credit hours.