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Link, Chris Associate Professor

Positions

Research Areas research areas

Research

research overview

  • The long-term goal of our research is to understand the cellular and molecular basis of age-associated neurodegenerative diseases, such as Alzheimer's disease (AD) and Amyotrophic Lateral Sclerosis (ALS). The major focus of our studies has been the identification of the cellular and molecular mechanisms by which specific proteins central to these diseases (e.g., the beta amyloid peptide in AD and TDP-43 in ALS) induce pathology. Our primary approach has been to develop transgenic C. elegans strains that express these human proteins, often resulting in abnormal phenotypes that can be the basis of classic genetic screens. The overall rationale for this approach is that invertebrate models allow facile 'pilot' studies that are time-consuming, difficult, or impossible in other systems. We complement the C. elegans studies using mammalian cell culture and bioinformatic analysis of mouse and human deep sequencing data.

keywords

  • modeling human neurodegenerative diseases using cellular and C. elegans models

Publications

selected publications

Teaching

courses taught

  • IPHY 3060 - Cell Physiology
    Primary Instructor - Fall 2018
  • IPHY 4060 - Cell Physiology
    Primary Instructor - Fall 2019 / Fall 2020 / Spring 2021
    Focuses on the molecular machines and cellular sub-compartments that allow cells to renew, replicate, and function in the context of multicellular organisms. Students must enroll in lecture and lab sections.
  • IPHY 4870 - Honors Thesis
    Primary Instructor - Spring 2019
    Department enforced prerequisites: IPHY 2800 and IPHY 3700.
  • IPHY 6010 - Seminar
    Primary Instructor - Spring 2021
    Presents special topics in integrative physiology. May be repeated up to 6 total credit hours.
  • IPHY 6830 - Professional Skills for the Research Scientist
    Primary Instructor - Fall 2019
    Discusses grant and manuscript writing, scientific presentations, peer-review, setting up/directing a research laboratory, research ethics, mentoring and other professional skills.
  • IPHY 6840 - Research Project
    Primary Instructor - Spring 2021
    Involves a scholarly investigation of a selected topic using literature and/or experimental techniques. Advisor required. May be repeated up to 3 total credit hours.

Background

International Activities

global connections related to teaching and scholarly work (in recent years)

Other Profiles