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Link, Chris Associate Professor

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Research Areas research areas

Research

research overview

  • The Link laboratory uses the simple nematode worm Caenorhabditis elegans to study the basic biology of human neurodegenerative diseases, including Alzeheimer's Disease (AD) and Amyotrophic Lateral Sclerosis (ALS). The key assumptions are that some of the molecular and cellular events underlying neurodegenerative pathology are likely to occur even in a simple metazoan such as C. elegans, and the experimental advantages of this model system will simplify understanding these events. Our general approach is to: 1) construct transgenic C. elegans animals expressing human proteins causally associated with neurodegenerative diseases, 2) determine the resulting physiological effects, 3) seek to determine the molecular basis of these effects, and 4) extend these insights to mammalian models and the human disease itself.

keywords

  • modeling human neurodegenerative diseases using cellular and C. elegans models

Publications

selected publications

Background

International Activities

global connections related to teaching and scholarly work (in recent years)