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Link, Chris Associate Professor

Positions

Research Areas research areas

Research

research overview

  • The long-term goal of our research is to understand the cellular and molecular basis of age-associated neurodegenerative diseases, such as Alzheimer's disease (AD) and Amyotrophic Lateral Sclerosis (ALS). The major focus of our studies has been the identification of the cellular and molecular mechanisms by which specific proteins central to these diseases (e.g., the beta amyloid peptide in AD and TDP-43 in ALS) induce pathology. Our primary approach has been to develop transgenic C. elegans strains that express these human proteins, often resulting in abnormal phenotypes that can be the basis of classic genetic screens. The overall rationale for this approach is that invertebrate models allow facile 'pilot' studies that are time-consuming, difficult, or impossible in other systems. We complement the C. elegans studies using mammalian cell culture and bioinformatic analysis of mouse and human deep sequencing data.

keywords

  • modeling human neurodegenerative diseases using cellular and C. elegans models

Publications

selected publications

Teaching

courses taught

  • IPHY 4860 Independent Study: Undergraduate (Spring 2019)
  • IPHY 4870 Honors Thesis (Spring 2019)
  • IPHY 4930 Internship (Spring 2019)
  • IPHY 5840 Graduate Independent Study (Spring 2019)
  • IPHY 6840 Research Project (Spring 2019)
  • IPHY 6950 Master's Thesis (Spring 2019)
  • IPHY 8990 Doctoral Dissertation (Spring 2019)
  • IPHY 5840 Graduate Independent Study (Fall 2018)
  • IPHY 6840 Research Project (Fall 2018)
  • IPHY 6950 Master's Thesis (Fall 2018)
  • IPHY 8990 Doctoral Dissertation (Fall 2018)
  • IPHY 2910 Practicum in Integrative Physiology (Summer 2018)
  • IPHY 4860 Independent Study: Undergraduate (Summer 2018)
  • IPHY 4930 Internship (Summer 2018)
  • IPHY 5840 Graduate Independent Study (Summer 2018)
  • IPHY 6840 Research Project (Summer 2018)
  • IPHY 6950 Master's Thesis (Summer 2018)
  • IPHY 8990 Doctoral Dissertation (Summer 2018)
  • IPHY 2910 Practicum in Integrative Physiology (Spring 2018)
  • IPHY 4860 Independent Study: Undergraduate (Spring 2018)
  • IPHY 4870 Honors Thesis (Spring 2018)
  • IPHY 4930 Internship (Spring 2018)
  • IPHY 5840 Graduate Independent Study (Spring 2018)
  • IPHY 6840 Research Project (Spring 2018)
  • IPHY 6950 Master's Thesis (Spring 2018)
  • IPHY 8990 Doctoral Dissertation (Spring 2018)

Background

International Activities

global connections related to teaching and scholarly work (in recent years)

Other Profiles