The long-term goal of our research is to understand the cellular and molecular basis of age-associated neurodegenerative diseases, such as Alzheimer's disease (AD) and Amyotrophic Lateral Sclerosis (ALS). The major focus of our studies has been the identification of the cellular and molecular mechanisms by which specific proteins central to these diseases (e.g., the beta amyloid peptide in AD and TDP-43 in ALS) induce pathology. Our primary approach has been to develop transgenic C. elegans strains that express these human proteins, often resulting in abnormal phenotypes that can be the basis of classic genetic screens. The overall rationale for this approach is that invertebrate models allow facile 'pilot' studies that are time-consuming, difficult, or impossible in other systems. We complement the C. elegans studies using mammalian cell culture and bioinformatic analysis of mouse and human deep sequencing data.
modeling human neurodegenerative diseases using cellular and C. elegans models
IPHY 4060 - Cell Physiology
Fall 2019 / Fall 2020 / Spring 2021
Focuses on the molecular machines and cellular sub-compartments that allow cells to renew, replicate, and function in the context of multicellular organisms. Students must enroll in lecture and lab sections.