The plant triterpenoid celastrol blocks PINK1-dependent mitophagy by disrupting PINK1's association with the mitochondrial protein TOM20
Journal Article
Overview
publication date
- May 3, 2019
has subject area
- Autophagy - Mitophagy
- Biochemical Phenomena - Protein Binding
- Carrier Proteins - Membrane Transport Proteins
- Cell Line - HeLa Cells
- Cell Physiological Phenomena - Membrane Potential, Mitochondrial
- Electrophysiological Phenomena - Membrane Potential, Mitochondrial
- Energy Metabolism - Membrane Potential, Mitochondrial
- Epithelial Cells - HeLa Cells
- HSP90 Heat-Shock Proteins
- Humans
- Hydrazones
- Membrane Proteins - Membrane Transport Proteins
- Metabolism - Protein Binding
- Microtubules
- Mitochondrial Turnover - Mitophagy
- Pentacyclic Triterpenes
- Polymerization
- Protein Kinases
- Receptors, Cell Surface
- Tripterygium
- Triterpenes
- Tumor Cells, Cultured - HeLa Cells
- Ubiquitin-Protein Ligases
has restriction
- green
Date in CU Experts
- March 20, 2019 9:52 AM
Full Author List
- Zhang C; Wang R; Liu Z; Bunker E; Lee S; Giuntini M; Chapnick D; Liu X
author count
- 8
citation count
- 16
published in
- Journal of Biological Chemistry Journal
Other Profiles
International Standard Serial Number (ISSN)
- 0021-9258
Electronic International Standard Serial Number (EISSN)
- 1083-351X
Digital Object Identifier (DOI)
Additional Document Info
start page
- 7472
end page
- 7487
volume
- 294
issue
- 18