Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain
Journal Article
Overview
publication date
- November 1, 2019
has subject area
- Animals
- Antigens, Surface - Lymphocyte Antigen 96
- Biochemical Phenomena - Signal Transduction
- Biological Factors - Interleukin-1beta
- Biological Factors - Interleukin-1beta
- Biological Factors - Tumor Necrosis Factor-alpha
- Biological Factors - Tumor Necrosis Factor-alpha
- Blood Proteins - Tumor Necrosis Factor-alpha
- Carrier Proteins - Lymphocyte Antigen 96
- Cell Line, Transformed - RAW 264.7 Cells
- Cell Physiological Phenomena - Signal Transduction
- Cells - Microglia
- Cells - RAW 264.7 Cells
- Culture Techniques - Primary Cell Culture
- Cyclooxygenase 2
- DNA-Binding Proteins - NF-kappa B
- Diagnostic Techniques and Procedures - Primary Cell Culture
- Female
- Gene Expression Regulation
- Hydrocarbons, Aromatic - Lovastatin
- Inorganic Chemicals - Nitric Oxide
- Investigative Techniques - Primary Cell Culture
- Investigative Techniques - Primary Cell Culture
- Male
- Mice
- Multiprotein Complexes - NF-kappa B
- Nervous System - Microglia
- Nitrogen Compounds - Nitric Oxide
- Nitrogen Compounds - Nitric Oxide
- Nuclear Proteins - NF-kappa B
- Oxygen Compounds - Nitric Oxide
- Peptides - Interleukin-1beta
- Peptides - Interleukin-1beta
- Peptides - Tumor Necrosis Factor-alpha
- Peptides - Tumor Necrosis Factor-alpha
- Peripheral Nervous System Diseases - Neuralgia
- Polycyclic Compounds - Lovastatin
- Proteins - Interleukin-1beta
- Proteins - Interleukin-1beta
- Proteins - Tumor Necrosis Factor-alpha
- Proteins - Tumor Necrosis Factor-alpha
- Proteins - Tumor Necrosis Factor-alpha
- Rats
- Rats, Sprague-Dawley
- Signs and Symptoms - Neuralgia
- Spinal Cord Dorsal Horn
- Toll-Like Receptor 4
- Transcription Factors - NF-kappa B
has restriction
- closed
Date in CU Experts
- September 24, 2019 4:50 AM
Full Author List
- Peng Y; Zhang X; Zhang T; Grace PM; Li H; Wang Y; Li H; Chen H; Watkins LR; Hutchinson MR
author count
- 12
citation count
- 42
published in
- Brain, Behavior, and Immunity Journal
Other Profiles
International Standard Serial Number (ISSN)
- 0889-1591
Electronic International Standard Serial Number (EISSN)
- 1090-2139
Digital Object Identifier (DOI)
Additional Document Info
start page
- 432
end page
- 444
volume
- 82