Associative and non-associative mechanisms of morphine analgesic tolerance are neurochemically distinct in the rat spinal cord
Journal Article
Overview
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Administration, Intravenous - Injections, Intravenous
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Animals
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Behavior, Animal
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Carrier Proteins - Receptors, N-Methyl-D-Aspartate
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Central Nervous System Agents - Analgesics, Opioid
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Central Nervous System Agents - Analgesics, Opioid
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Drug Tolerance
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Environment and Public Health - Analysis of Variance
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Health Care Evaluation Mechanisms - Analysis of Variance
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Heterocyclic Compounds, 4 or More Rings - Morphine
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Heterocyclic Compounds, Bridged-Ring - Morphine
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Hydrocarbons, Aromatic - Dizocilpine Maleate
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Injections - Injections, Intravenous
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Investigative Techniques - Analysis of Variance
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Male
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Membrane Proteins - Receptors, N-Methyl-D-Aspartate
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Membrane Proteins - Receptors, N-Methyl-D-Aspartate
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Molecular Mechanisms of Pharmacological Action - Excitatory Amino Acid Antagonists
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Nerve Tissue Proteins - Neurotensin
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Opiate Alkaloids - Morphine
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Pain Measurement
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Peptides - Neurotensin
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Pharmacological Phenomena - Dose-Response Relationship, Drug
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Physiological Effects of Drugs - Analgesics, Opioid
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Physiological Effects of Drugs - Excitatory Amino Acid Antagonists
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Polycyclic Compounds - Dizocilpine Maleate
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Polycyclic Compounds - Morphine
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Rats
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Rats, Sprague-Dawley
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Receptors, Glutamate - Receptors, N-Methyl-D-Aspartate
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Sensory System Agents - Analgesics, Opioid
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Spinal Cord
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Toxicological Phenomena - Dose-Response Relationship, Drug
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Grisel JE; Watkins LR; Maier SF
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