Alcohol-induced sedation and synergistic interactions between alcohol and morphine: A key mechanistic role for Toll-like receptors and MyD88-dependent signaling
Journal Article
Overview
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Animal Population Groups - Mice, Knockout
Animals
Animals, Inbred Strains - Mice, Inbred BALB C
Biochemical Phenomena - Signal Transduction
Biological Factors - Interleukin-1beta
Biological Factors - Interleukin-1beta
Carrier Proteins - Myeloid Differentiation Factor 88
Cell Physiological Phenomena - Signal Transduction
Central Nervous System
Central Nervous System Agents - Analgesics, Opioid
Central Nervous System Agents - Analgesics, Opioid
Central Nervous System Agents - Central Nervous System Depressants
DNA-Binding Proteins - NF-kappa B
Diagnostic Techniques, Neurological - Reflex, Abnormal
Drug Synergism
Ethanol
Heterocyclic Compounds, 4 or More Rings - Morphine
Heterocyclic Compounds, Bridged-Ring - Morphine
Male
Mice
Mice - Mice, Inbred BALB C
Mice - Mice, Knockout
Mice, Mutant Strains - Mice, Knockout
Nervous System Diseases - Reflex, Abnormal
Nervous System Physiological Phenomena - Reflex, Abnormal
Nuclear Proteins - NF-kappa B
Opiate Alkaloids - Morphine
Peptides - Interleukin-1beta
Peptides - Interleukin-1beta
Peptides - Myeloid Differentiation Factor 88
Physical Examination - Reflex, Abnormal
Physiological Effects of Drugs - Analgesics, Opioid
Physiological Effects of Drugs - Central Nervous System Depressants
Polycyclic Compounds - Morphine
Proteins - Interleukin-1beta
Proteins - Interleukin-1beta
Proteins - Myeloid Differentiation Factor 88
Receptors, G-Protein-Coupled - Receptors, Opioid, mu
Receptors, Neurotransmitter - Receptors, Opioid, mu
Receptors, Peptide - Receptors, Opioid, mu
Sensory System Agents - Analgesics, Opioid
Signs and Symptoms - Reflex, Abnormal
Toll-Like Receptor 2
Toll-Like Receptor 4
Transcription Factors - NF-kappa B
Full Author List
Corrigan F; Wu Y; Tuke J; Coller JK; Rice KC; Diener KR; Hayball JD; Watkins LR; Somogyi AA; Hutchinson MR
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