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Publications in VIVO

Perkins, Thomas T. Professor Adjoint


Research Areas research areas


research overview

  • Single molecule studies are increasingly important in biophysics. The Perkins group focuses on developing high precision single-molecule techniques and applying them to answer a variety of biological questions, such as: how motor proteins transduce chemical energy into physical motion? And, how does the structure and dynamics of membrane proteins affect their functions? We developed a single-molecule optical-trapping assay with Ångström-scale stability and resolution in all three dimensions (3D). We are applying these techniques to study DNA-based molecular motors, the folding/unfolding kinetics of RNA structures, and DNA overstretching. We also developed focused-ion beam modified cantilevers for dramatically improved performance of atomic force microscopy and are currently pursuing studies of diverse biological systems (globular proteins, protein-ligand bonds, membrane proteins, structured RNA).


  • biophysics, single molecule, membrane protein, DNA, RNA, molecule motors,atomic force microscopy, optical trapping, picoscale force standards, nanotechnology, nanoscience


selected publications


International Activities

global connections related to teaching and scholarly work (in recent years)

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