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Publications in VIVO

Perkins, Thomas T. Assoc Professor Adjoint


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research overview

  • Single molecule studies are increasingly important in biophysics. The Perkins group focuses on developing precision single-molecule techniques and applying them to answer a variety of biological questions, such as: how motor proteins transduce chemical energy into physical motion? And, how does the structure and dynamics of membrane proteins affect their functions? We developed a single-molecule optical-trapping assay with Ångström-scale stability and resolution in all three dimensions (3D). We are applying these techniques to study DNA-based molecular motors, the folding/unfolding kinetics of RNA structures, DNA overstretching and biologically derived force standards. We also developed an atomic force microscope that is a 100-fold more stable than current state of the art as well as improving the force stabilty and force precision of bio-AFM. We are currently pursuing applications of focus-ion-beam modified cantilevers to protein folding studies.


  • biophysics, single molecule, membrane protein, DNA, RNA, molecule motors,atomic force microscopy, optical trapping, picoscale force standards, nanotechnology, nanoscience


selected publications

International Activities

global connections related to teaching and scholarly work (in recent years)

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