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Publications in VIVO
 

Shen, Jingshi Associate Professor

Positions

Research Areas research areas

Research

research overview

  • The overarching goal of my group is to uncover the regulatory principles of vesicle-mediated cargo transport. In a NIGMS-funded project, we are systematically dissecting mammalian vesicle transport using unbiased genetic screens. We then use biochemical, genetic, and cell biological tools to uncover the molecular mechanisms of the new regulators identified in the screens. In a NIDDK-funded project, we investigate how insulin regulates the trafficking of the glucose transporter GLUT4 and how this process is impaired in type 2 diabetes. Finally, in a recent NIA-funded project, we aim to identify the machinery mediating exosomal cargo transport between cells.

keywords

  • cell biology of the membrane, neurotransmitter release, glucose homeostasis

Publications

selected publications

Teaching

courses taught

  • MCDB 3145 - Molecular Cell Biology II
    Primary Instructor - Spring 2019
    Examines intracellular mechanisms, including transport of ions and small molecules across membranes; protein targeting to organelles; membrane trafficking between organelles; signal transduction; the cytoskeleton; and the cell cycle. Analysis of these activities is from the experimental perspective established in MCDB 3135. Recommended prerequisite: MCDB 3135 (minimum grade C-), and recommended prerequisite or corequisite of MCDB 3140 concurrent with either this class or MCDB 3135.
  • MCDB 4425 - Topics in Membrane Biology: Cell Biology, Physiology and Disease
    Primary Instructor - Spring 2018 / Spring 2019 / Spring 2020
    Students will apply their knowledge of basic biology to exploring several of the most exciting topics in biomedicine including protein folding and stress responses, nutrient sensing and balance and signal transduction across membranes. Emphasis will be placed upon human physiology and associated human diseases including Alzheimer's disease, diabetes and cardiovascular disease. Fulfills MCDB scientific reasoning requirement. Recommended prerequisites: MCDB 3135 and MCDB 3145 (minimum grade C-) or instructor consent required. Same as MCDB 5425.
  • MCDB 4980 - Honors Research
    Primary Instructor - Fall 2019
    Provides faculty-supervised research for students who have been approved by the departmental honors committee. Normally taken during the semester before completion of the honors thesis. Recommended prerequisite: MCDB 4840 or comparable research experience, and minimum GPA of 3.20.
  • MCDB 4990 - Honors Thesis
    Primary Instructor - Fall 2019
    Involves the preparation and defense of an honors thesis, based on faculty-supervised original research, including final phases of the research project. Recommended prerequisites: MCDB 4840 or MCDB 4980 or comparable research experience, and minimum GPA of 3.3 and approval by the MCDB Honors Committee.
  • MCDB 5425 - Topics in Membrane Biology: Cell Biology, Physiology and Disease
    Primary Instructor - Spring 2018 / Spring 2019 / Spring 2020
    Students will apply their knowledge of basic biology to exploring several of the most exciting topics in biomedicine including protein folding and stress responses, nutrient sensing and balance and signal transduction across membranes. Emphasis will be placed upon human physiology and associated human diseases including Alzheimer's disease, diabetes and cardiovascular disease. Same as MCDB 4425.
  • MCDB 6000 - Introduction to Laboratory Methods
    Primary Instructor - Spring 2018 / Spring 2019 / Spring 2020
    Introduces methodology and techniques used in biological research. Designed as a tutorial between a few students and one faculty member. Students are expected to read original research papers, discuss findings, and to plan and execute experiments in selected areas. Open only to MCDB graduate students. May be repeated up to 9 total credit hours.

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