Methods for estimating heritability and investigating the genetic architecture of complex traits. Recent work focuses on the heritability and genetic architecture of human psychiatric disorders and substance use and dependence. This includes identifying genetic variants that contribute to disorder liability, integrating whole genome and transcriptome data, understanding gene-by-environment interactions, and testing how these factors influence risk prediction. Selection and adaptation. Identifying quantitative and molecular signatures of selection, both recent positive selection and purifying selection. Using large-scale reciprocal transplant experiments to test gene-by-environment interaction hypotheses and to understand how environments shape complex traits in humans and in other species. Much of this work has been with the ecologically and economically important tree genus, Populus, but also with Salix.
EBIO 3080 - Evolutionary Biology
Spring 2019 / Fall 2019
Lect. and lab. Emphasizes the fundamental evolutionary concepts that provide explanations for the diversification of life on Earth. Specific topics include the evidence for evolution, adaptation by natural selection, speciation, systematics, molecular and genome evolution, and macroevolutionary patterns and processes. Recitations allow students to explore specific topics in more depth and smaller groups. Recommended prerequisites: EBIO 1210 and EBIO 1220 (minimum grade C-). Degree credit not granted for this course and EBIO 3680.