Hydrocarbons, Aromatic - Doxorubicin
PubMed MeSh Term
Overview
subject area of
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A redox pathway leading to the alkylation of nucleic acids by doxorubicin and related anthracyclines: Application to the design of antitumor drugs for resistant cancer Journal Article
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Alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin Journal Article
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Antiestrogen binding site and estrogen receptor mediate uptake and distribution of 4-hydroxytamoxifen-targeted doxorubicin-formaldehyde conjugate in breast cancer cells. Journal Article
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CDK8 is a stimulus-specific positive coregulator of p53 target genes Journal Article
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Carboxylesterase-2 is a highly sensitive target of the antiobesity agent orlistat with profound implications in the activation of anticancer prodrugs Journal Article
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Chemical ionization mass spectrometric determination of acrolein in human breast cancer cells Journal Article
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Click Nucleic Acid Mediated Loading of Prodrug Activating Enzymes in PEG-PLGA Nanoparticles for Combination Chemotherapy Journal Article
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DOXORUBICIN-INDUCED SKIN NECROSIS IN THE SWINE MODEL - PROTECTION WITH A NOVEL RADICAL DIMER Journal Article
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Design principles of drug combinations for chemotherapy Journal Article
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Design, synthesis, and biological evaluation of doxorubicin - Formaldehyde conjugates targeted to breast cancer cells Journal Article
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Design, synthesis, and preliminary evaluation of doxazolidine carbamates as prodrugs activated by carboxylesterases Journal Article
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Doxazolidine induction of apoptosis by a topoisomerase II independent mechanism Journal Article
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Doxazolidine, a proposed active metabolite of doxorubicin that cross-links DNA Journal Article
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Doxoform and daunoform: Anthracycline-formaldehyde conjugates toxic to resistant tumor cells Journal Article
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Doxorubicin-formaldehyde conjugate, Doxoform: Induction of apoptosis relative to doxorubicin Journal Article
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Doxorubicin-formaldehyde conjugates targeting alpha(v)beta(3) integrin Journal Article
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EXPERIMENTAL CHEMOTHERAPY-INDUCED SKIN NECROSIS IN SWINE - MECHANISTIC STUDIES OF ANTHRACYCLINE ANTIBIOTIC TOXICITY AND PROTECTION WITH A RADICAL DIMER COMPOUND Journal Article
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Epidoxoform: A hydrolytically more stable anthracycline-formaldehyde conjugate toxic to resistant tumor cells Journal Article
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Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program Journal Article
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Identification of human intestinal carboxylesterase as the primary enzyme for activation of a doxazolidine carbamate prodrug Journal Article
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Lack of glutathione conjugation to adriamycin in human breast cancer MCF-7/DOX cells - Inhibition of glutathione S-transferase P1-1 by glutathione conjugates from anthracyclines Journal Article
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Mass spectrometric measurement of formaldehyde generated in breast cancer cells upon treatment with anthracycline antitumor drugs Journal Article
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Nuclear targeting and nuclear retention of anthracycline-formaldehyde conjugates implicates DNA covalent bonding in the cytotoxic mechanism of anthracyclines Journal Article
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PREVENTION OF ADRIAMYCIN TOXICITY Journal Article
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Perfusion-guided sonopermeation of neuroblastoma: a novel strategy for monitoring and predicting liposomal doxorubicin uptake in vivo Journal Article
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Preclinical Efficacy of a Carboxylesterase 2-Activated Prodrug of Doxazolidine Journal Article
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Production of formaldehyde and DNA-adriamycin or DNA-daunomycin adducts, initiated through redox chemistry of dithiothreitol/iron, xanthine oxidase/NADH/iron, or glutathione/iron Journal Article
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RADICAL DIMER RESCUE OF TOXICITY AND IMPROVED THERAPEUTIC INDEX OF ADRIAMYCIN IN TUMOR-BEARING MICE Journal Article
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Rational design and synthesis of androgen receptor-targeted nonsteroidal anti-androgen ligands for the tumor-specific delivery of a doxorubicin-formaldehyde conjugate Journal Article
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Redox pathway leading to the alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin Journal Article
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Studies of targeting and intracellular trafficking of an anti-androgen doxorubicin-formaldehyde conjugate in PC-3 prostate cancer cells bearing androgen receptor-GFP chimera Journal Article
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Supramolecular Stacking of Doxorubicin on Carbon Nanotubes for In Vivo Cancer Therapy Journal Article
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Synthesis and Biological Characterization of Protease-Activated Prodrugs of Doxazolidine Journal Article
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The RNase PARN Controls the Levels of Specific miRNAs that Contribute to p53 Regulation Journal Article
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TiO2-Capped Gold Nanorods for Plasmon-Enhanced Production of Reactive Oxygen Species and Photothermal Delivery of Chemotherapeutic Agents Journal Article
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p53 regulates enhancer accessibility and activity in response to DNA damage Journal Article
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