When to believe what you see. Journal Article uri icon



  • The recent X-ray crystal structure of a hammerhead ribozyme derived from Schistosoma mansoni containing the rate-enhancing peripheral domain has a catalytic core that is very different from the catalytic core present in the structure of the "minimal" hammerhead, which lacks a peripheral domain (Martick and Scott, 2006). The new structure reconciles many of the disagreements between the minimal hammerhead structure and the biochemical data on the cleavage properties of chemically modified hammerheads. The new structure also emphasizes the dynamic nature of small RNA domains and provides a cautionary tale for everyone who tries to use structure to understand function.

publication date

  • August 1, 2006

has restriction

  • hybrid

Date in CU Experts

  • March 13, 2015 12:56 PM

Full Author List

  • Nelson JA; Uhlenbeck OC

author count

  • 2

Other Profiles

International Standard Serial Number (ISSN)

  • 1097-2765

Additional Document Info

start page

  • 447

end page

  • 450


  • 23


  • 4