EVIDENCE THAT TRICYCLIC SMALL MOLECULES MAY POSSESS TOLL-LIKE RECEPTOR AND MYELOID DIFFERENTIATION PROTEIN 2 ACTIVITY
Journal Article
Overview
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Animal Population Groups - Mice, Knockout
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Animals
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Animals, Inbred Strains - Mice, Inbred BALB C
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Antigens, Surface - Lymphocyte Antigen 96
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Biochemical Phenomena - Protein Binding
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Biochemical Phenomena - Signal Transduction
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Biological Factors - Interleukin-1
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Biological Factors - Interleukin-1
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Biological Factors - Tumor Necrosis Factor-alpha
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Biological Factors - Tumor Necrosis Factor-alpha
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Blood Proteins - Tumor Necrosis Factor-alpha
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Carrier Proteins - Lymphocyte Antigen 96
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Carrier Proteins - Myeloid Differentiation Factor 88
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Cell Physiological Phenomena - Signal Transduction
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Cells - Microglia
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Cells, Cultured
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Central Nervous System Agents - Analgesics, Opioid
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Central Nervous System Agents - Analgesics, Opioid
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Heterocyclic Compounds, 3-Ring
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Heterocyclic Compounds, 4 or More Rings - Morphine
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Heterocyclic Compounds, Bridged-Ring - Morphine
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Humans
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Ligands
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Male
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Metabolism - Protein Binding
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Mice
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Mice - Mice, Inbred BALB C
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Mice - Mice, Knockout
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Mice, Mutant Strains - Mice, Knockout
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Models, Molecular
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Nervous System - Microglia
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Opiate Alkaloids - Morphine
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Pain Measurement
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Peptides - Interleukin-1
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Peptides - Interleukin-1
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Peptides - Myeloid Differentiation Factor 88
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Peptides - Tumor Necrosis Factor-alpha
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Peptides - Tumor Necrosis Factor-alpha
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Physiological Effects of Drugs - Analgesics, Opioid
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Polycyclic Compounds - Morphine
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Proteins - Interleukin-1
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Proteins - Interleukin-1
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Proteins - Myeloid Differentiation Factor 88
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Proteins - Tumor Necrosis Factor-alpha
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Proteins - Tumor Necrosis Factor-alpha
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Proteins - Tumor Necrosis Factor-alpha
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Rats
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Sensory System Agents - Analgesics, Opioid
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Toll-Like Receptor 2
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Toll-Like Receptor 4
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Toll-Like Receptors
Full Author List
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Hutchinson MR; Loram LC; Zhang Y; Shridhar M; Rezvani N; Berkelhammer D; Phipps S; Foster PS; Landgraf K; Falke JJ
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