3'-AZIDOTHYMIDINE (ZIDOVUDINE) INHIBITS GLYCOSYLATION AND DRAMATICALLY ALTERS GLYCOSPHINGOLIPID SYNTHESIS IN WHOLE CELLS AT CLINICALLY RELEVANT CONCENTRATIONS
Journal Article
Overview
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Antiviral Agents - Reverse Transcriptase Inhibitors
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Biochemical Phenomena - Carbohydrate Sequence
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Biochemical Phenomena - DNA Replication
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Biochemical Phenomena - Glycosylation
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Biochemical Phenomena - Kinetics
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Biochemical Phenomena - Structure-Activity Relationship
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Carbohydrate Conformation
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Cell Line
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Deoxyribonucleosides - Zidovudine
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Diagnostic Techniques, Radioisotope - Radioisotope Dilution Technique
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Dideoxynucleosides - Zidovudine
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Elements - Tritium
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Galactose
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Gases - Tritium
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Genetic Phenomena - DNA Replication
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Glycoconjugates - Glycosphingolipids
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Golgi Apparatus
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Hexosamines
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Humans
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Indicator Dilution Techniques - Radioisotope Dilution Technique
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Leukemia, Myeloid, Acute - Leukemia, Erythroblastic, Acute
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Lipids - Glycosphingolipids
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Mechanical Phenomena - Kinetics
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Metabolism - Glycosylation
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Molecular Sequence Data
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Molecular Sequence Data - Carbohydrate Sequence
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Myeloproliferative Disorders - Leukemia, Erythroblastic, Acute
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Nucleic Acid Synthesis Inhibitors - Reverse Transcriptase Inhibitors
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Nucleic Acids, Nucleotides, and Nucleosides - Zidovudine
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Organic Chemistry Phenomena - Glycosylation
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Pharmacological Phenomena - Dose-Response Relationship, Drug
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Pharmacological Phenomena - Structure-Activity Relationship
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Pyrimidines - Zidovudine
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Radioisotopes - Tritium
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Sphingolipids - Glycosphingolipids
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Toxicological Phenomena - Dose-Response Relationship, Drug
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Tumor Cells, Cultured
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Date in CU Experts
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September 6, 2013 4:49 AM
Full Author List
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YAN JP; ILSLEY DD; FROHLICK C; STEET R; HALL ET; KUCHTA RD; MELANCON P
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