We are studying the mechanism of DNA replication in a variety of contexts. These include the development of an in vitro herpes replication system that uses a minicircle template, examining the thermodynamics of DNA replication, elucidating the features of a base-pair that a polymerase recognizes in order to accurately and efficiently synthesize it, and test method for delivering nucleotides to cells that bypass the salvage machinery.
keywords
DNA replication, polymerase, primase, fidelity, base-pair, herpes, human, nanotechnology
