Inhibitors of PARP: Number crunching and structure gazing Journal Article

• Best Open Access

Overview

CU Boulder Authors

• Rudolph, Johannes
• Luger, Karolin

publication date

• March 15, 2022

has subject area

• Animals
• Antineoplastic Agents
• Antineoplastic Agents - Poly(ADP-ribose) Polymerase Inhibitors
• Biochemical Phenomena - DNA Repair
• Biochemical Phenomena - Molecular Structure
• Biochemical Phenomena - Protein Binding
• Biochemical Phenomena - Structure-Activity Relationship
• Chemical Phenomena - Molecular Structure
• Enzyme Inhibitors - Poly(ADP-ribose) Polymerase Inhibitors
• Fanconi Anemia Complementation Group Proteins - BRCA1 Protein
• Fanconi Anemia Complementation Group Proteins - BRCA2 Protein
• Genetic Phenomena - DNA Repair
• Humans
• Investigative Techniques - Drug Evaluation, Preclinical
• Investigative Techniques - Drug Evaluation, Preclinical
• Metabolism - Protein Binding
• Models, Molecular
• Mutation
• Nuclear Proteins - BRCA1 Protein
• Nuclear Proteins - BRCA2 Protein
• Pharmacological Phenomena - Dose-Response Relationship, Drug
• Pharmacological Phenomena - Structure-Activity Relationship
• Phosphoproteins - BRCA1 Protein
• Poly(ADP-ribose) Polymerases
• Protein Interaction Domains and Motifs
• Synthetic Lethal Mutations
• Toxicological Phenomena - Dose-Response Relationship, Drug
• Transcription Factors - BRCA1 Protein
• Tumor Suppressor Proteins - BRCA1 Protein
• Tumor Suppressor Proteins - BRCA2 Protein

has restriction

• hybrid

Date in CU Experts

• April 8, 2022 10:55 AM

Full Author List

• Rudolph J; Jung K; Luger K

author count

• 3

citation count

• 70

published in

• Proceedings of the National Academy of Sciences of USA  Journal

Other Profiles

International Standard Serial Number (ISSN)

• 0027-8424

Electronic International Standard Serial Number (EISSN)

• 1091-6490

Digital Object Identifier (DOI)

• https://doi.org/10.1073/pnas.2121979119

Additional Document Info

volume

• 119

issue

• 11

number

• ARTN e2121979119