Characterizing primary transcriptional responses to short term heat shock in Down syndrome. Journal Article uri icon

Overview

abstract

  • Heat shock stress induces genome-wide changes in transcription regulation, activating a coordinated cellular response to enable survival. We noticed many heat shock genes are up-regulated in blood samples from individuals with trisomy 21. We characterized the immediate transcriptional response to heat shock of two lymphoblastoid cell lines derived from brothers with and without trisomy 21. The trisomy 21 cells displayed a more robust heat shock response after just one hour at 42°C than the matched disomic cells.

publication date

  • January 1, 2024

Date in CU Experts

  • August 9, 2024 10:42 AM

Full Author List

  • Cardiello JF; Westfall J; Dowell R; Allen MA

author count

  • 4

Other Profiles

Electronic International Standard Serial Number (EISSN)

  • 1932-6203

Additional Document Info

start page

  • e0307375

volume

  • 19

issue

  • 8