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Dowell, Robin D. Associate Professor

Positions

Research Areas research areas

Research

research overview

  • The Dowell lab seeks to uncover the core principles behind the genetics of transcription. Specifically, we use a number of experimental and computational approaches to compare closely related individuals to discover the underlying mechanistic principles of transcriptional regulation. In yeast, we use naturally occurring strains, molecular biology, and genetics to identify the mechanistic basis of differential transcriptional regulation. In humans, we have been using nascent sequencing (GRO-seq, PRO-seq, others) to study the response of polymerase to changes in TF activity. As much of our work leverages novel data, such as precision run-on sequencing (PRO-seq), or integrates across diverse large-scale datasets (RNA-seq, ChIP-seq, ATAC-seq, 3-seq, etc), we must frequently develop new computational approaches in order to answer interesting biological questions.

keywords

  • Computational biology, comparative genomics, systems biology, machine learning, probabilistic modeling, Down syndrome, personalized medicine

Publications

selected publications

Teaching

courses taught

  • CHEM 6901 - Research in Chemistry
    Primary Instructor - Fall 2018
    May be repeated up to 15 total credit hours.
  • CSCI 4830 - Special Topics in Computer Science
    Primary Instructor - Spring 2018 / Spring 2019
    Covers topics of interest in computer science at the senior undergraduate level. Content varies from semester to semester. Only 9 credit hours from CSCI 4830 and/or CSCI 4831 can count toward Computer Science BS or BA.
  • CSCI 7000 - Current Topics in Computer Science
    Primary Instructor - Spring 2018 / Spring 2019
    Covers research topics of current interest in computer science that do not fall into a standard subarea. May be repeated up to 8 total credit hours.
  • MCDB 4520 - Bioinformatics and Genomics
    Primary Instructor - Spring 2018 / Spring 2019
    Computational and experimental methods in bioinformatics and genomics, and how these methods provide insights into protein structure and function, molecular evolution, biological diversity, cell biology and human disease. Topics include database searching, multiple sequence alignment, molecular phylogeny, microarrays, proteomics and pharmacogenomics. Recommended prerequisites: MCDB 3135 or CHEM 4700 (minimum grade C-). Same as MCDB 5520.
  • MCDB 4521 - Bioinformatics and Genomics Laboratory
    Primary Instructor - Spring 2018 / Spring 2019
    Provides experience with, and exposure to, computational and experimental methods in bioinformatics and genomics. Meets once a week. Students are expected to read original research papers, discuss findings, plan and execute data analysis in selected areas. Same as MCDB 5521.
  • MCDB 5520 - Bioinformatics and Genomics
    Primary Instructor - Spring 2018 / Spring 2019
    Computational and experimental methods in bioinformatics and genomics, and how these methods provide insights into protein structure and function, molecular evolution, biological diversity, cell biology and human disease. Topics include database searching, multiple sequence alignment, molecular phylogeny, microarrays, proteomics and pharmacogenomics. Same as MCDB 4520.
  • MCDB 5521 - Bioinformatics and Genomics Laboratory
    Primary Instructor - Spring 2018 / Spring 2019
    Provides experience with, and exposure to, computational and experimental methods in bioinformatics and genomics. Meets once a week. Students are expected to read original research papers, discuss findings, plan and execute data analysis in selected areas. Same as MCDB 4521
  • MCDB 6000 - Introduction to Laboratory Methods
    Primary Instructor - Spring 2018 / Spring 2019 / Spring 2020
    Introduces methodology and techniques used in biological research. Designed as a tutorial between a few students and one faculty member. Students are expected to read original research papers, discuss findings, and to plan and execute experiments in selected areas. Open only to MCDB graduate students. May be repeated up to 9 total credit hours.

Background

International Activities

global connections related to teaching and scholarly work (in recent years)

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