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Publications in VIVO
 

Dowell, Robin D. Associate Professor

Positions

Research Areas research areas

Research

research overview

  • The Dowell lab seeks to uncover the core principles behind the genetics of transcription. Specifically, we use a number of experimental and computational approaches to compare closely related individuals to discover the underlying mechanistic principles of transcriptional regulation. In yeast, we use naturally occurring strains, molecular biology, and genetics to identify the mechanistic basis of differential transcriptional regulation. In humans, we have been using nascent sequencing (GRO-seq, PRO-seq, others) to study the response of polymerase to changes in TF activity. As much of our work leverages novel data, such as precision run-on sequencing (PRO-seq), or integrates across diverse large-scale datasets (RNA-seq, ChIP-seq, ATAC-seq, 3-seq, etc), we must frequently develop new computational approaches in order to answer interesting biological questions.

keywords

  • Computational biology, comparative genomics, systems biology, machine learning, probabilistic modeling, Down syndrome, personalized medicine

Publications

selected publications

Teaching

courses taught

  • CSCI 4830 Special Topics in Computer Science (Spring 2019)
  • CSCI 4900 Upper Division, Undergraduate Level Independent Study (Spring 2019)
  • CSCI 7000 Current Topics in Computer Science (Spring 2019)
  • CSCI 8990 Doctoral Dissertation (Spring 2019)
  • MCDB 4520 Bioinformatics and Genomics (Spring 2019)
  • MCDB 4521 Bioinformatics and Genomics Laboratory (Spring 2019)
  • MCDB 5520 Bioinformatics and Genomics (Spring 2019)
  • MCDB 5521 Bioinformatics and Genomics Laboratory (Spring 2019)
  • MCDB 6000 Introduction to Laboratory Methods (Spring 2019)
  • MCDB 8990 Doctoral Dissertation (Spring 2019)
  • CHEM 6901 Research in Chemistry (Fall 2018)
  • CSCI 8990 Doctoral Dissertation (Fall 2018)
  • MCDB 4840 Upper-Division Independent Study (Fall 2018)
  • MCDB 4980 Honors Research (Fall 2018)
  • MCDB 7840 Graduate Independent Study (Fall 2018)
  • MCDB 8990 Doctoral Dissertation (Fall 2018)
  • MCDB 4840 Upper-Division Independent Study (Summer 2018)
  • MCDB 8990 Doctoral Dissertation (Summer 2018)
  • CSCI 4830 Special Topics in Computer Science (Spring 2018)
  • CSCI 4900 Upper Division, Undergraduate Level Independent Study (Spring 2018)
  • CSCI 7000 Current Topics in Computer Science (Spring 2018)
  • CSCI 8990 Doctoral Dissertation (Spring 2018)
  • MCDB 4520 Bioinformatics and Genomics (Spring 2018)
  • MCDB 4521 Bioinformatics and Genomics Laboratory (Spring 2018)
  • MCDB 5520 Bioinformatics and Genomics (Spring 2018)
  • MCDB 5521 Bioinformatics and Genomics Laboratory (Spring 2018)
  • MCDB 6000 Introduction to Laboratory Methods (Spring 2018)
  • MCDB 8990 Doctoral Dissertation (Spring 2018)

Background

International Activities

global connections related to teaching and scholarly work (in recent years)

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