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Hoenger, Andreas Professor

Positions

Research Areas research areas

Research

research overview

  • My main research interests are functional and structural analyses by 3-D cryo-electron microscopy of cytoskeletal assemblies and large macromolecular structures as well as cellular organelles. We apply cryo-electron tomography to investigate the structure function relationships of large macromolecular assemblies and cellular organelles within their native cytosolic environment. We operate two electron microscopes with the latest data recording systems, and peripheral equipment for specimen preparation and data analysis. Our projects are the following: Giardia cytoskeleton, Large-scale supermontages of entire mammalian cells, development of high-density labels for cryo-electron microscopy, structure-function analysis of vimentin and desmin intermediate filaments, development of vitrified sections for high-resolution molecular structures in cells and tissues, and the development of software for data acquisition, tomographic 3-D reconstruction, and image processing.

keywords

  • Cellbiology and Cytoskeleton assemblies, 3-D reconstruction of macromolecular assemblies and cellular organelles by cryo-electron microscopy, cryo-electron tomography

Publications

selected publications

Teaching

courses taught

  • MCDB 3501 - Structural Methods for Biological Macromolecules
    Primary Instructor - Fall 2018 / Fall 2019
    Teaches fundamental knowledge about protein structures, protein interactions and protein folding. Discusses in detail the most common methods on how proteins and macromolecular complexes are studied, such as X-ray crystallography, NMR-spectroscopy and electron microscopy. Offers about 50 percent direct teaching, 40 percent discussion of papers in a journal club style and 10 percent hands-on practicals on software packages relevant to structural biology. Recommended prerequisite: MCDB 2150 or EBIO 2070 (minimum grade C-). Formerly MCDB 4501.
  • MCDB 4100 - Special Topics
    Primary Instructor - Spring 2019 / Summer 2019
    May be repeated up to 6 total credit hours. Recommended prerequisites: MCDB 3135 and MCDB 3145 (minimum grade C-).
  • MCDB 4980 - Honors Research
    Primary Instructor - Fall 2019
    Provides faculty-supervised research for students who have been approved by the departmental honors committee. Normally taken during the semester before completion of the honors thesis. Recommended prerequisite: MCDB 4840 or comparable research experience, and minimum GPA of 3.20.
  • MCDB 4990 - Honors Thesis
    Primary Instructor - Fall 2019
    Involves the preparation and defense of an honors thesis, based on faculty-supervised original research, including final phases of the research project. Recommended prerequisites: MCDB 4840 or MCDB 4980 or comparable research experience, and minimum GPA of 3.3 and approval by the MCDB Honors Committee.
  • MCDB 6000 - Introduction to Laboratory Methods
    Primary Instructor - Spring 2018
    Introduces methodology and techniques used in biological research. Designed as a tutorial between a few students and one faculty member. Students are expected to read original research papers, discuss findings, and to plan and execute experiments in selected areas. Open only to MCDB graduate students. May be repeated up to 9 total credit hours.

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