research overview
- My main research interests are functional and structural analyses by 3-D cryo-electron microscopy of cytoskeletal assemblies and macromolecular structures as well as cellular organelles. We apply cryo-electron tomography to investigate the structure function relationships of large macromolecular assemblies and cellular organelles within their native cytosolic environment. We operate two electron microscopes with the latest data recording systems, and peripheral equipment for specimen preparation and data analysis. I received funding to create a new Cryo-Electron Tomography facility (CU-Boulder Center for Cryo-ET: CCET, total funding about $8M). This will add a new FIBSEM microscope plus various peripheral equipment to the University and to MCD-Biology.