keywords
- traumatic brain injury, sleep, inflammation, microglia, aging, neurodegenerative diseases
- Contact Info
Rowe, Rachel Kathleen
Positions
- Assistant Professor, Integrative Physiology
Research Areas
Research
Publications
selected publications
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chapter
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Fluid Percussion Model of Traumatic Brain Injury.
Neuromethods.
97-110.
2018
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Midline (Central) Fluid Percussion Model of Traumatic Brain Injury.
Methods in Molecular Biology.
211-230.
2016
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Fluid Percussion Model of Traumatic Brain Injury.
Neuromethods.
97-110.
2018
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conference proceeding
- Traumatic brain injury characteristics predictive of subsequent sleep-wake disturbances in pediatric patients. Brain Injury. 223-224. 2023
- ALPHA-II SPECTRIN N-TERMINAL FRAGMENT (SNTF) DETECTS AXONAL PATHOLOGY IN CHRONIC EXPERIMENTAL TRAUMATIC BRAIN INJURY. Journal of Neurotrauma. A108-A108. 2023
- DIFFUSE TRAUMATIC BRAIN INJURY ALTERED FUNCTION OF THE GROWTH HORMONE AXIS IN JUVENILE RATS. Journal of Neurotrauma. A71-A71. 2023
- METHODS MATTER: MECHANISM OF TRAUMATIC BRAIN INJURY DRIVES SUBSTANTIAL POST-TRAUMATIC SLEEP DIFFERENCES. Journal of Neurotrauma. A71-A71. 2023
- NOVEL SPATIAL QUANTIFICATION SHOWED GLIALNEURON INTERACTIONS AFTER TBI. Journal of Neurotrauma. A70-A71. 2023
- POST INJURY SLEEP FRAGMENTATION STRESS INCREASES NEUROINFLAMMATORY RESPONSE AND IMPAIRS BEHAVIORAL RECOVERY. Journal of Neurotrauma. A135-A135. 2023
- SEX DIFFERENCES IN SLEEP: BIOLOGICAL SEX AND BRAIN INJURY SEVERITY IMPACT SLEEP IN THE MOUSE. Journal of Neurotrauma. A71-A71. 2023
- TBI-INDUCED SENSORIMOTOR DEFICITS DIFFER AS A FUNCTION OF SEX AND INJURY SEVERITY. Journal of Neurotrauma. A7-A7. 2023
- BLOOD-BRAIN BARRIER DYSFUNCTION PREDICTS MICROGLIAL ACTIVATION FOLLOWING TBI IN JUVENILE RATS. Journal of Neurotrauma. A77-A77. 2022
- FIBRILLIN-1 MUTATION ACCELERATES CEREBROVASCULAR AGING AND INCREASES NEUROVASCULAR VULNERABILITY TO MILD TRAUMATIC BRAIN INJURY. Journal of Neurotrauma. A5-A6. 2022
- SLEEP FRAGMENTATION FOLLOWING TRAUMATIC BRAIN INJURY EXACERBATES SUB-ACUTE BEHAVIORAL DEFICITS AND TRANSCRIPTIONAL CHANGES AT CHRONIC TIME POINTS. Journal of Neurotrauma. A2-A2. 2022
- TRAUMATIC BRAIN INJURY CHARACTERISTICS PREDICTIVE OF SUBSEQUENT SLEEP-WAKE DISTURBANCES IN PEDIATRIC PATIENTS. Journal of Neurotrauma. A85-A85. 2022
- A GENE THERAPY APPROACH TO TREAT PERSISTENT PAIN DERIVED FROM SPINAL STUDIES OF RODENTS AND MONKEYS. Journal of Neurotrauma. A121-A121. 2021
- AGING WITH BRAIN INJURY: AGE-AT-INJURY INFLUENCES THE GLIAL RESPONSE TO TBI IN JUVENILES. Journal of Neurotrauma. A60-A60. 2021
- COLONY STIMULATING FACTOR-1 RECEPTOR INHIBITION AS A PHARMACODYNAMIC MECHANISM TO TRACK PERIPHERAL INFLAMMATION AFTER TBI. Journal of Neurotrauma. A12-A12. 2021
- INCREASED TGF-B/MMP LEVELS ACCELERATE CEREBROVASCULAR AGING, LEAVING THE BRAIN MORE VULNERABLE TO TBI. Journal of Neurotrauma. A68-A69. 2021
- REM SLEEP IS DISRUPTED FOLLOWING PEDIATRIC TBI. Journal of Neurotrauma. A107-A107. 2021
- AGING WITH BRAIN INJURY: AGE-AT-INJURY INFLUENCES THE GLIAL RESPONSE TO TBI IN JUVENILES. Journal of Neurotrauma. A6-A7. 2021
- A NOVEL GLYCOSYLATED PITUITARY ADENYLATE CYCLASE-ACTIVATING PEPTIDE ATTENUATED FUNCTIONAL DEFICITS FOLLOWING EXPERIMENTAL TBI. Journal of Neurotrauma. A91-A91. 2019
- ASSOCIATED RISK FACTORS TO PREDICT PEDIATRIC NON-ACCIDENTAL HEAD TRAUMA. Journal of Neurotrauma. A138-A138. 2019
- DIFFUSE BRAIN INJURY INDUCED BIOMARKERS ASSOCIATED WITH TOXIC PROTEIN VARIANTS FOUND IN ALZHEIMER'S DISEASE AND RELATED DEMENTIA. Journal of Neurotrauma. A30-A30. 2019
- DISSECTING MOLECULAR MECHANISM AND THERAPEUTIC IMPACT OF REMOTE ISCHEMIC CONDITIONING IN A MOUSE MODEL OF DIFFUSE TRAUMATIC BRAIN. Journal of Neurotrauma. A124-A125. 2019
- MICE BORN TO MOTHERS WITH GESTATIONAL BRAIN INJURY HAVE DISTORTED BRAIN CIRCUITRY AND DIFFERENTIAL IMMUNE RESPONSES. Journal of Neurotrauma. A137-A138. 2019
- REMOTE ISCHEMIC CONDITIONING PREVENTS TRAUMATIC BRAIN INJURY-INDUCED ACUTE LUNG INJURY. Journal of Neurotrauma. A7-A8. 2019
- SELF-GUIDED REHABILITATION IMPROVED COGNITIVE PERFORMANCE AFTER DIFFUSE TRAUMATIC BRAIN INJURY IN JUVENILE RATS. Journal of Neurotrauma. A138-A138. 2019
- TRAUMATIC BRAIN INJURY AND ALZHEIMER'S DISEASE IN AGED MICE LEADS TO SIMILAR INCREASES IN SLEEP AND PERIPHERAL CD115 EXPRESSION. Journal of Neurotrauma. A23-A23. 2019
- CLINICAL OBSERVATION INFORMS TRANSLATIONAL RESEARCH OF GROWTH HORMONE AXIS DISRUPTION FOLLOWING DIFFUSE TBI IN JUVENILE RATS. Journal of Neurotrauma. A112-A112. 2018
- GLIAL ENGAGEMENT AT THE HEMATOMA AFTER INTRACEREBRAL HEMORRHAGE IN THE MOUSE. Journal of Neurotrauma. A124-A124. 2018
- NEUROINFLAMMATION AND ACUTE SLEEP DISTURBANCES FOLLOWING EXPERIMENTAL INTRACEREBRAL HEMORRHAGE. Journal of Neurotrauma. A263-A263. 2018
- PRE-PUBERTY AND PERI-PUBERTY TBI: AGE AT INJURY EFFECTS ON HISTOPATHOLOGICAL OUTCOMES FOLLOWING DIFFUSE BRAIN INJURY IN RATS. Journal of Neurotrauma. A133-A133. 2018
- REMOTE ISCHEMIC CONDITIONING ATTENUATES THE PERIPHERAL COMPONENT OF NEUROINFLAMMATION IN DIFFUSE BRAIN-INJURED IN FEMALE MICE. Journal of Neurotrauma. A222-A222. 2018
- SEXUAL DIMORPHISM IN ACUTE INFLAMMATION AND POST-TRAUMATIC SLEEP FOLLOWING DIFFUSE TRAUMATIC BRAIN INJURY IN THE MOUSE. Journal of Neurotrauma. A125-A125. 2018
- TRAUMATIC BRAIN INJURY-INDUCED NEURONAL DAMAGE INDUCES CORTICAL ROD MICROGLIA THAT PROMOTE PERSISTENT NEUROINFLAMMATION. Journal of Neurotrauma. A12-A13. 2018
- AGE-AT-INJURY AFFECTS CHRONIC DIFFUSE TRAUMATIC BRAIN INJURY AND ALZHEIMER'S DISEASE RELATED BEHAVIORS AND PATHOLOGIES. Journal of Neurotrauma. A12-A12. 2017
- INVESTIGATION OF NANOPARTICLE ACCUMULATION AFTER EXPERIMENTAL BRAIN INJURY. Journal of Neurotrauma. A26-A26. 2016
- ACUTE OVER-THE-COUNTER PHARMACOLOGICAL INTERVENTION DOES NOT ADVERSELY AFFECT BEHAVIORAL OUTCOME FOLLOWING DIFFUSE TRAUMATIC BRAIN. Journal of Neurotrauma. A109-A109. 2014
- EXPERIMENTAL DIFFUSE BRAIN INJURY LEADS TO CHRONIC ENDOCRINE DYSFUNCTION. Journal of Neurotrauma. A99-A99. 2014
- MIDLINE FLUID PERCUSSION INJURY IN THE DEVELOPING RODENT RESULTS IN DIFFUSE INJURY AND DEVIATION OF THE NEUROVASCULAR UNIT. Journal of Neurotrauma. A64-A64. 2014
- REMOTE ISCHEMIC CONDITIONING AS PRE-HOSPITAL THERAPEUTIC INTERVENTION FOR DIFFUSE TRAUMATIC BRAIN INJURY. Journal of Neurotrauma. A109-A109. 2014
- EXPERIMENTAL DIFFUSE BRAIN INJURY DOES NOT IMPACT CHRONIC SLEEP PATTERNS. Journal of Neurotrauma. A127-A128. 2013
- IMMEDIATE POST-INJURY SLEEP DISRUPTION DOES NOT AFFECT FUNCTIONAL OUTCOME FOLLOWING DIFFUSE BRAIN INJURY IN MICE. Journal of Neurotrauma. A9-A10. 2013
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journal article
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Deep sleep helps the heart to heal..
Nature.
2024
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Quantifying microglial morphology: an insight into function.
Clinical and Experimental Immunology.
221-229.
2024
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Sleep, inflammation, and hemodynamics in rodent models of traumatic brain injury.
Frontiers in Neuroscience.
2024
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Blood-Brain Barrier Dysfunction Predicts Microglial Activation After Traumatic Brain Injury in Juvenile Rats.
Neurotrauma Reports.
95-116.
2024
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Diffuse traumatic brain injury substantially alters plasma growth hormone in the juvenile rat.
Journal of Endocrinology.
2024
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Traumatic brain injury in mice generates early-stage Alzheimer's disease related protein pathology that correlates with neurobehavioral deficits.
2023
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Colony-Stimulating Factor-1 Receptor Inhibition Transiently Attenuated the Peripheral Immune Response to Experimental Traumatic Brain Injury.
Neurotrauma Reports.
284-296.
2023
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Comparisons of quantitative approaches for assessing microglial morphology reveal inconsistencies, ecological fallacy, and a need for standardization.
Scientific Reports.
2022
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Reactive morphology of dividing microglia following kainic acid administration.
Frontiers in Neuroscience.
2022
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Microglia Are Necessary to Regulate Sleep after an Immune Challenge.
Biology.
2022
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Immune-endocrine interactions in the pathophysiology of sleep-wake disturbances following traumatic brain injury: A narrative review.
Brain Research Bulletin.
117-128.
2022
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Intimate Partner Violence, Clinical Indications, and Other Family Risk Factors Associated With Pediatric Abusive Head Trauma.
Journal of Interpersonal Violence: concerned with the study and treatment of victims and perpetrators of physical and sexual violence.
NP6785-NP6812.
2022
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Time Course of Remote Neuropathology Following Diffuse Traumatic Brain Injury in the Male Rat.
Experimental neurobiology.
105-115.
2022
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Traumatic Brain Injury Characteristics Predictive of Subsequent Sleep-Wake Disturbances in Pediatric Patients.
Biology.
2022
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Age-At-Injury Influences the Glial Response to Traumatic Brain Injury in the Cortex of Male Juvenile Rats.
Frontiers in Neurology.
2022
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Design and Synthesis of Brain Penetrant Glycopeptide Analogues of PACAP With Neuroprotective Potential for Traumatic Brain Injury and Parkinsonism.
2022
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Mice Born to Mothers with Gravida Traumatic Brain Injury Have Distorted Brain Circuitry and Altered Immune Responses.
Journal of Neurotrauma.
2862-2880.
2021
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Age-at-Injury Determines the Extent of Long-Term Neuropathology and Microgliosis After a Diffuse Brain Injury in Male Rats.
Frontiers in Neurology.
2021
- POPULATION-LEVEL EPIDEMIOLOGY OF CONCUSSION CONCURRENT WITH DOMESTIC VIOLENCE IN ARIZONA, USA. Journal of Neurotrauma. A34-A34. 2021
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Experimental diffuse brain injury and a model of Alzheimer's disease exhibit disease-specific changes in sleep and incongruous peripheral inflammation.
Journal of Neuroscience Research.
1136-1160.
2021
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Evaluating abusive head trauma in children < 5 years old: Risk factors and the importance of the social history.
Journal of Pediatric Surgery.
390-396.
2021
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Remote Ischemic Conditioning Reduced Acute Lung Injury After Traumatic Brain Injury in the Mouse.
Shock.
256-267.
2021
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Failure to Thrive in a 15-month-old with a History of Head Trauma..
Pediatrics in Review.
S55-S59.
2021
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Spatial Distribution of Neuropathology and Neuroinflammation Elucidate the Biomechanics of Fluid Percussion Injury.
Neurotrauma Reports.
59-75.
2021
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Sex-Dependent Pathology in the HPA Axis at a Sub-acute Period After Experimental Traumatic Brain Injury.
Frontiers in Neurology.
2020
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The Bidirectional Relationship Between Sleep and Inflammation Links Traumatic Brain Injury and Alzheimer's Disease.
Frontiers in Neuroscience.
2020
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Proteomic analysis identifies plasma correlates of remote ischemic conditioning in the context of experimental traumatic brain injury.
Scientific Reports.
2020
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Acute peripheral inflammation and post-traumatic sleep differ between sexes after experimental diffuse brain injury.
European Journal of Neuroscience.
2791-2814.
2020
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Longitudinal optical imaging technique to visualize progressive axonal damage after brain injury in mice reveals responses to different minocycline treatments.
Scientific Reports.
2020
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Intracerebral hemorrhage in the mouse altered sleep-wake patterns and activated microglia.
Experimental Neurology.
2020
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Epidemiology of Pediatric Traumatic Brain Injury and Hypothalamic-Pituitary Disorders in Arizona.
Frontiers in Neurology.
2020
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Mild and Moderate Traumatic Brain Injury and Repeated Stress Affect Corticosterone in the Rat.
Neurotrauma Reports.
113-124.
2020
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Acute Post-Traumatic Sleep May Define Vulnerability to a Second Traumatic Brain Injury in Mice.
Journal of Neurotrauma.
1318-1334.
2019
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Influence of Schizophrenia-Associated Gene Egr3 on Sleep Behavior and Circadian Rhythms in Mice.
Journal of Biological Rhythms.
662-670.
2018
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Traumatic brain injury-induced neuronal damage in the somatosensory cortex causes formation of rod-shaped microglia that promote astrogliosis and persistent neuroinflammation.
Glia.
2719-2736.
2018
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Blood-brainbarrier disruption dictates nanoparticle accumulation following experimental brain injury.
Nanomedicine: Nanotechnology, Biology and Medicine.
2155-2166.
2018
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Simultaneous Cryosectioning of Multiple Rodent Brains.
Journal of Visualized Experiments.
2018
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Partial cage division significantly reduces aggressive behavior in male laboratory mice.
Laboratory Animals.
384-393.
2018
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Midline (central) fluid percussion model of traumatic brain injury in pediatric and adolescent rats.
Journal of Neurosurgery: Pediatrics.
22-30.
2018
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Novel TNF receptor-1 inhibitors identified as potential therapeutic candidates for traumatic brain injury.
Journal of Neuroinflammation.
2018
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Quantitative microglia analyses reveal diverse morphologic responses in the rat cortex after diffuse brain injury.
Scientific Reports.
2017
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Aging with a traumatic brain injury: Could behavioral morbidities and endocrine symptoms be influenced by microglial priming?.
Brain, Behavior, and Immunity.
1-7.
2017
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Diffuse traumatic brain injury affects chronic corticosterone function in the rat.
Endocrine Connections.
152-166.
2016
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Diffuse traumatic brain injury induces prolonged immune dysregulation and potentiates hyperalgesia following a peripheral immune challenge.
Molecular Pain.
2016
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MW151 Inhibited IL-1 beta Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses.
PLoS One.
2016
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Experimental diffuse brain injury results in regional alteration of gross vascular morphology independent of neuropathology.
Brain Injury.
217-224.
2016
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Aging with Traumatic rain Injury: Effects of Age at Injury on Behavioral Outcome following Diffuse Brain Injury in Rats.
Developmental Neuroscience.
195-205.
2016
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Clinical relevance of midline fluid percussion brain injury: Acute deficits, chronic morbidities and the utility of biomarkers.
Brain Injury.
1293-1301.
2016
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Lipid mediators of inflammation in neurological injury: shifting the balance toward resolution.
Neural Regeneration Research.
77-78.
2016
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Resolvins AT-D1 and E1 differentially impact functional outcome, post-traumatic sleep, and microglial activation following diffuse brain injury in the mouse.
Brain, Behavior, and Immunity.
131-140.
2015
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Acute over-the-counter pharmacological intervention does not adversely affect behavioral outcome following diffuse traumatic brain injury in the mouse.
Experimental Brain Research.
2709-2719.
2014
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Diffuse brain injury does not affect chronic sleep patterns in the mouse.
Brain Injury.
504-510.
2014
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Recovery of Neurological Function Despite Immediate Sleep Disruption Following Diffuse Brain Injury in the Mouse: Clinical Relevance to Medically Untreated Concussion.
Sleep.
743-752.
2014
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Diffuse Brain Injury Induces Acute Post-Traumatic Sleep.
PLoS One.
2014
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Using anesthetics and analgesics in experimental traumatic brain injury.
Lab Animal.
286-291.
2013
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The p38α MAPK Regulates Microglial Responsiveness to Diffuse Traumatic Brain Injury.
The Journal of Neuroscience.
6143-6153.
2013
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EVALUATION OF RIGHT SUBPHRENIC FLUID COLLECTIONS WITH EMISSION COMPUTED-TOMOGRAPHY - AN EXPERIMENTAL-STUDY.
Computerized radiology : official journal of the Computerized Tomography Society.
319-323.
1985
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Deep sleep helps the heart to heal..
Nature.
2024
Teaching
courses taught
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IPHY 4010 - Seminar in Integrative Physiology
Primary Instructor - Spring 2023 / Fall 2024
Introduces a small group of students to current research topics in integrative physiology, evaluation of current research and discussion of critical issues. May be repeated up to 6 total credit hours when topics vary. Recommended prerequisite: Statistics course (IPHY 3280 or EBIO 1010 or MATH 2510 or PSYC 2111 or SOCY 2061). -
IPHY 4580 - Sleep Physiology
Primary Instructor - Fall 2024
Describes the physiology, neurobiology, and functions of sleep and circadian rhythms; explains the impact of sleep and circadian rhythms, as well as sleep and circadian disruptions and disorders on immune, endocrine, thermoregulatory, cardiovascular, respiratory, and neural systems; examines changes in sleep and circadian rhythms across the life span. The integrative nature of sleep and circadian rhythms in normal physiological and cognitive functions and their importance in health and disease processes will be emphasized. All registration restrictions will be strictly enforced by the department. Recommended prerequisites: Statistics course (IPHY 3280 or EBIO 1010 or MATH 2510 or PSYC 2111 or SOCY 2061). Same as IPHY 5580. -
IPHY 4870 - Honors Thesis
Primary Instructor - Spring 2024
An opportunity for students enrolled in the IPHY Honors program to earn academic credit for working on their thesis. Twenty-five hours of work is required for each hour of academic credit given. Consult for faculty mentor for approval. Recommended prerequisites: IPHY 3700; and IPHY 4850 (taken concurrently). -
IPHY 6010 - Seminar
Primary Instructor - Spring 2023 / Fall 2024
Presents special topics in integrative physiology. May be repeated up to 15 total credits.
Background
education and training
- Ph.D., University of Kentucky 2014
- B.S., Eastern Kentucky University 2007
International Activities
geographic focus
- Australia Country
- Brazil Country
- France Country
- Norway Country
- United Kingdom Country