Mediator kinase inhibition further activates super-enhancer-associated genes in AML
Journal Article
Overview
publication date
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Animals
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Animals, Inbred Strains - Mice, Inbred Strains
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Biochemical Phenomena - Down-Regulation
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Biochemical Phenomena - Enhancer Elements, Genetic
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Biochemical Phenomena - Up-Regulation
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Carrier Proteins - Cyclin-Dependent Kinase 8
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Cell Cycle - Cell Division
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Cell Cycle Proteins
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Cell Cycle Proteins - Cyclin-Dependent Kinase 8
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Cell Cycle Proteins - Cyclin-Dependent Kinases
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Cell Line - Cell Line, Tumor
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Cell Physiological Phenomena - Cell Division
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Cell Physiological Phenomena - Cell Lineage
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Disease Progression
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Female
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Gene Expression Regulation - Down-Regulation
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Gene Expression Regulation - Up-Regulation
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Gene Expression Regulation, Neoplastic
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Genes - Genes, Tumor Suppressor
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Genes, Neoplasm
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Genes, Neoplasm - Genes, Tumor Suppressor
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Genetic Phenomena - Cell Division
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Genetic Structures - Enhancer Elements, Genetic
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Growth - Cell Division
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Heterocyclic Compounds, 4 or More Rings
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Humans
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Leukemia, Myeloid, Acute
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Male
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Mice
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Mice - Mice, Inbred Strains
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Mice, SCID
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Morphogenesis - Cell Lineage
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Multiprotein Complexes - Cyclin-Dependent Kinase 8
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Nuclear Proteins
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Nuclear Proteins - Cyclin-Dependent Kinase 8
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Peptides - Cyclin-Dependent Kinase 8
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Peptides - Cyclin-Dependent Kinase 8
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Peptides - Cyclin-Dependent Kinases
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Pharmacological Phenomena - Down-Regulation
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Pharmacological Phenomena - Up-Regulation
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Polycyclic Compounds
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Proline-Directed Protein Kinases - Cyclin-Dependent Kinase 8
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Proline-Directed Protein Kinases - Cyclin-Dependent Kinases
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Proteins - Cyclin-Dependent Kinase 8
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Proteins - Cyclin-Dependent Kinase 8
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Proteins - Cyclin-Dependent Kinases
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Regulatory Elements, Transcriptional - Enhancer Elements, Genetic
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Reproduction - Cell Lineage
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Reproductive Physiological Phenomena - Cell Lineage
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Transcription Factors
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Tumor Cells, Cultured - Cell Line, Tumor
Full Author List
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Pelish HE; Liau BB; Nitulescu II; Tangpeerachaikul A; Poss ZC; Da Silva DH; Caruso BT; Arefolov A; Fadeyi O; Christie AL
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