Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as antagonists of toll-like receptor 4
Journal Article
Overview
publication date
has subject area
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Animals
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Antigens, Bacterial - Lipopolysaccharides
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Biological Factors - Interferon-beta
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Biological Factors - Interleukin-1beta
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Biological Factors - Interleukin-1beta
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Biological Factors - Tumor Necrosis Factor-alpha
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Biological Factors - Tumor Necrosis Factor-alpha
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Blood Physiological Phenomena - Phagocytosis
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Blood Proteins - Tumor Necrosis Factor-alpha
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Cell Line
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Cells - Macrophages, Peritoneal
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Cells - Microglia
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Cells, Cultured
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Central Nervous System Agents - Narcotic Antagonists
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Connective Tissue Cells - Macrophages, Peritoneal
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Endocytosis - Phagocytosis
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Endotoxins - Lipopolysaccharides
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Glycoconjugates - Lipopolysaccharides
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Heterocyclic Compounds, 4 or More Rings - Naloxone
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Heterocyclic Compounds, 4 or More Rings - Naltrexone
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Heterocyclic Compounds, Bridged-Ring - Naloxone
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Heterocyclic Compounds, Bridged-Ring - Naltrexone
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Immune System - Macrophages, Peritoneal
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Immune System Phenomena - Phagocytosis
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Immunity, Innate - Phagocytosis
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Inorganic Chemicals - Nitric Oxide
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Inorganic Chemicals - Reactive Oxygen Species
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Lipids - Lipopolysaccharides
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Male
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Mice
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Mononuclear Phagocyte System - Macrophages, Peritoneal
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Myeloid Cells - Macrophages, Peritoneal
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Nervous System - Microglia
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Nitrogen Compounds - Nitric Oxide
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Nitrogen Compounds - Nitric Oxide
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Opiate Alkaloids - Naloxone
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Opiate Alkaloids - Naltrexone
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Oxygen Compounds - Nitric Oxide
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Oxygen Compounds - Reactive Oxygen Species
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Peptides - Interferon-beta
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Peptides - Interleukin-1beta
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Peptides - Interleukin-1beta
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Peptides - Tumor Necrosis Factor-alpha
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Peptides - Tumor Necrosis Factor-alpha
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Physiological Effects of Drugs - Narcotic Antagonists
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Polycyclic Compounds - Naloxone
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Polycyclic Compounds - Naltrexone
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Polysaccharides - Lipopolysaccharides
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Proteins - Interferon-beta
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Proteins - Interleukin-1beta
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Proteins - Interleukin-1beta
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Proteins - Tumor Necrosis Factor-alpha
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Proteins - Tumor Necrosis Factor-alpha
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Proteins - Tumor Necrosis Factor-alpha
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Rats, Sprague-Dawley
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Sensory System Agents - Narcotic Antagonists
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Toll-Like Receptor 4
Full Author List
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Wang X; Zhang Y; Peng Y; Hutchinson MR; Rice KC; Yin H; Watkins LR
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