Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling
Journal Article
Overview
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Antigens, Surface - Receptor, ErbB-2
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Biochemical Phenomena - Biotinylation
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Biochemical Phenomena - Down-Regulation
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Biochemical Phenomena - Signal Transduction
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Biochemical Phenomena - Transcription, Genetic
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Biochemical Phenomena - Ubiquitination
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Biochemical Phenomena - Ubiquitination
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Biomarkers, Tumor - Receptor, ErbB-2
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Carrier Proteins - STAT3 Transcription Factor
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Cell Line - Cell Line, Tumor
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Cell Physiological Phenomena - Signal Transduction
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Chemical Phenomena - Dimerization
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Chemistry Techniques, Analytical - Immunoprecipitation
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Gene Expression - Transcription, Genetic
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Gene Expression Regulation - Down-Regulation
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Gene Expression Regulation - Ubiquitination
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Humans
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Immunologic Techniques - Immunoblotting
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Immunologic Techniques - Immunoprecipitation
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Isoantigens - Receptor, ErbB-2
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Lung Diseases - Carcinoma, Non-Small-Cell Lung
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Lung Diseases - Lung Neoplasms
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Lysosomes
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Metabolism - Biotinylation
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Metabolism - Dimerization
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Metabolism - Ubiquitination
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Molecular Probe Techniques - Biotinylation
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Molecular Probe Techniques - Immunoblotting
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Mutagenesis, Site-Directed
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Mutation
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Peptides - STAT3 Transcription Factor
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Pharmacological Phenomena - Down-Regulation
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Protein-Tyrosine Kinases - ErbB Receptors
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Protein-Tyrosine Kinases - Receptor, ErbB-2
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Proteins - STAT3 Transcription Factor
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Proto-Oncogene Proteins - Proto-Oncogene Proteins c-cbl
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Proto-Oncogene Proteins - Receptor, ErbB-2
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Receptors, Cell Surface - ErbB Receptors
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Receptors, Cell Surface - Receptor, ErbB-2
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Receptors, Growth Factor - ErbB Receptors
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Receptors, Growth Factor - Receptor, ErbB-2
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Respiratory Tract Diseases - Carcinoma, Non-Small-Cell Lung
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Respiratory Tract Diseases - Lung Neoplasms
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Thoracic Neoplasms - Carcinoma, Non-Small-Cell Lung
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Thoracic Neoplasms - Lung Neoplasms
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Transcription Factors - STAT3 Transcription Factor
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Tumor Cells, Cultured - Cell Line, Tumor
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Ubiquitin
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Ubiquitin-Protein Ligases - Proto-Oncogene Proteins c-cbl
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Date in CU Experts
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December 22, 2017 10:42 AM
Full Author List
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Shtiegman K; Kochupurakkal BS; Zwang Y; Pines G; Starr A; Vexler A; Citri A; Katz M; Lavi S; Ben-Basat Y
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