Toward the Rational Design of p53-Stabilizing Drugs: Probing the Surface of the Oncogenic Y220C Mutant
Journal Article
Overview
publication date
- January 29, 2010
has subject area
- 2-Propanol
- Antineoplastic Agents
- Binding Sites
- Biochemical Phenomena - Molecular Dynamics Simulation
- Biochemical Phenomena - Protein Binding
- Biological Science Disciplines - Drug Design
- Carrier Proteins - Tumor Suppressor Protein p53
- Chemistry - Drug Design
- Computer Simulation - Molecular Dynamics Simulation
- Crystallography, X-Ray
- DNA-Binding Proteins - Tumor Suppressor Protein p53
- Humans
- Investigative Techniques - Drug Design
- Ligands
- Metabolism - Protein Binding
- Models, Molecular - Molecular Dynamics Simulation
- Mutation
- Neoplasms
- Nuclear Proteins - Tumor Suppressor Protein p53
- Phosphoproteins - Tumor Suppressor Protein p53
- Protein Conformation
- Protein Stability
- Tumor Suppressor Proteins - Tumor Suppressor Protein p53
has restriction
- bronze
Date in CU Experts
- May 19, 2020 10:57 AM
Full Author List
- Basse N; Kaar JL; Settanni G; Joerger AC; Rutherford TJ; Fersht AR
author count
- 6
citation count
- 90
published in
- Chemistry and Biology Journal
Other Profiles
International Standard Serial Number (ISSN)
- 1074-5521
Electronic International Standard Serial Number (EISSN)
- 1879-1301
Digital Object Identifier (DOI)
Additional Document Info
start page
- 46
end page
- 56
volume
- 17
issue
- 1