The research is my laboratory is broadly focused on the intersection of chemical and biological engineering with protein engineering, structural biology, and biophysics. Our research specifically seeks to develop novel functional materials and routes to material synthesis by exploiting the properties and natural diversity of biological molecules. At the core of this research is the study of how the function of proteins, namely enzymes, is impacted by their environment, including at “extreme” (i.e. non-natural) solvent and material interfaces. An understanding of the link between enzyme structure, conformational dynamics, activity, and microenvironment is a requisite for using enzymes in new and sophisticated ways.
Biocatalysis, Nonaqueous enzymology, Protein structure and function at material interfaces, Protein engineering, Biofuels, Tissue engineering, Bioremediation