Essential and separable roles for Syndecan-3 and Syndecan-4 in skeletal muscle development and regeneration. Journal Article uri icon

Overview

abstract

  • Syndecan-3 and syndecan-4 function as coreceptors for tyrosine kinases and in cell adhesion. Syndecan-3(-/-) mice exhibit a novel form of muscular dystrophy characterized by impaired locomotion, fibrosis, and hyperplasia of myonuclei and satellite cells. Explanted syndecan-3(-/-) satellite cells mislocalize MyoD, differentiate aberrantly, and exhibit a general increase in overall tyrosine phosphorylation. Following induced regeneration, the hyperplastic phenotype is recapitulated. While there are fewer apparent defects in syndecan-4(-/-) muscle, explanted satellite cells are deficient in activation, proliferation, MyoD expression, myotube fusion, and differentiation. Further, syndecan-4(-/-) satellite cells fail to reconstitute damaged muscle, suggesting a unique requirement for syndecan-4 in satellite cell function.

publication date

  • September 1, 2004

Full Author List

  • Cornelison DD; Wilcox-Adelman SA; Goetinck PF; Rauvala H; Rapraeger AC; Olwin BB

Other Profiles

Additional Document Info

start page

  • 2231

end page

  • 2236

volume

  • 18

issue

  • 18