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Olwin, Brad Professor

Positions

Research Areas research areas

Research

research overview

  • Our research group is investigating the mechanisms that regulate skeletal muscle regeneration, focusing on skeletal muscle stem cells. We are interested in the biogenesis of skeletal muscle stem cells and understanding the failure of these cells to maintain the skeletal musculature in neuromuscular diseases. An additional interest is focused on understanding the molecular basis and cell biology of skeletal muscle loss during aging. We are funded by the National Institutes of Arthritis and Musculoskeletal Diseases, and the Muscular Dystrophy Association.

keywords

  • Skeletal muscle regeneration, aging, stem cell biology

Publications

selected publications

Teaching

courses taught

  • MCDB 4615 - Biology of Stem Cells
    Primary Instructor - Fall 2020
    Stem cells have received considerable notice in both the scientific and social arena. Examines the stem cell concept by a critical examination of the primary scientific literature. Topics will include pluripotency and plasticity, environment, technology, self-renewal, transdifferentiation, molecular signature, epigenetic programming and stem cell versus cancer cell. Fulfills MCDB scientific reasoning requirement. Recommended prerequisite: MCDB 3135 or MCDB 3145 or instructor consent required. Same as MCDB 5615.
  • MCDB 4680 - Mechanisms of Aging
    Primary Instructor - Fall 2018
    Studies aging as a developmental process emphasizing genetic, cellular and molecular mechanisms. Fulfills MCDB scientific reasoning requirement. Recommended prerequisites: MCDB 3135 and MCDB 3145 (minimum grade C-). Same as MCDB 5680.
  • MCDB 4990 - Honors Thesis
    Primary Instructor - Spring 2018 / Spring 2019 / Spring 2020
    Involves the preparation and defense of an honors thesis, based on faculty-supervised original research, including final phases of the research project. Recommended prerequisites: MCDB 4840 or MCDB 4980 or comparable research experience, and minimum GPA of 3.3 and approval by the MCDB Honors Committee.
  • MCDB 5615 - Biology of Stem Cells
    Primary Instructor - Fall 2020
    Stem cells have received considerable notice in both the scientific and social arena. Examines the stem cell concept by a critical examination of the primary scientific literature. Topics will include pluripotency and plasticity, environment, technology, self-renewal, transdifferentiation, molecular signature, epigenetic programming and stem cell versus cancer cell. Fulfills MCDB scientific reasoning requirement. Same as MCDB 4615.
  • MCDB 5680 - Mechanisms of Aging
    Primary Instructor - Fall 2018
    Studies aging as a developmental process emphasizing genetic, cellular and molecular mechanisms. Same as MCDB 4680.
  • MCDB 6000 - Introduction to Laboratory Methods
    Primary Instructor - Spring 2020 / Spring 2021
    Introduces methodology and techniques used in biological research. Designed as a tutorial between a few students and one faculty member. Students are expected to read original research papers, discuss findings, and to plan and execute experiments in selected areas. May be repeated up to 15 total credit hours.
  • MCDB 6440 - Special Topics in MCD Biology
    Primary Instructor - Fall 2018 / Fall 2019
    Acquaints students with various topics not normally covered in the curriculum. Offered intermittently or upon student demand, and often presented by visiting professors. May be repeated up to 4 total credit hours.

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