Genes and Development Journal

Overview

publication venue for

• Learning from the worm: the effectiveness of protein-bound Moco to treat Moco deficiency 2021
• Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription 2020
• Structure and mechanism of the RNA polymerase II transcription machinery 2020
• Regulation of histone methylation by automethylation of PRC2 2019
• Is it time to take R(epressive) out of PRC1? 2019
• Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits 2018
• Neat1 is a p53-inducible lincRNA essential for transformation suppression 2017
• Finding the start site: redefining the human initiator element 2017
• Targeted CRISPR disruption reveals a role for RNase MRP RNA in human preribosomal RNA processing 2017
• Time to move the fat 2016
• Nucleotide levels regulate germline proliferation through modulating GLP-1/Notch signaling in C. elegans 2016
• Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers 2015
• Intestinal apical polarity mediates regulation of TORC1 by glucosylceramide in C. elegans 2015
• Human telomerase: biogenesis, trafficking, recruitment, and activation 2015
• linc-HOXA1 is a noncoding RNA that represses Hoxa1 transcription in cis 2013
• Fat chance for longevity 2013
• The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator 2013
• FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2 2012
• Delta Np63 alpha represses anti-proliferative genes via H2A.Z deposition 2012
• The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling (vol 26, pg 803, 2012) 2012
• RNase P branches out from RNP to protein: organelle-triggered diversification? 2012
• The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling 2012
• Quantitative functions of Argonaute proteins in mammalian development 2012
• Regulation of maternal phospholipid composition and IP3-dependent embryonic membrane dynamics by a specific fatty acid metabolic event in C. elegans 2012
• Suppression of progenitor differentiation requires the long noncoding RNA ANCR 2012
• Phactr4 regulates directional migration of enteric neural crest through PP1, integrin signaling, and cofilin activity 2012
• Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses 2011
• HEB and E2A function as SMAD/FOXH1 cofactors 2011
• The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity 2011
• Polycistronic pre-mRNA processing in vitro: snRNP and pre-mRNA role reversal in trans-splicing 2010
• Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding 2010
• Functional interaction between telomere protein TPP1 and telomerase 2010
• Differential regulation of p53 target genes: it's (core promoter) elementary 2010
• Human POT1 is required for efficient telomere C-rich strand replication in the absence of WRN 2009
• A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint 2009
• Nucleosome-binding affinity as a primary determinant of the nuclear mobility of the pioneer transcription factor FoxA 2009
• The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function 2009
• Histone H2B ubiquitination: the cancer connection 2008
• A branched-chain fatty acid is involved in post-embryonic growth control in parallel to the insulin receptor pathway and its biosynthesis is feedback-regulated in C-elegans 2008
• A dermal HOX transcriptional program regulates site-specific epidermal fate 2008
• Axin and GSK3-β control Smad3 protein stability and modulate TGF-β signaling 2008
• Axin and GSK3-β control Smad3 protein stability and modulate TGF-β signaling 2008
• Control of sex-specific apoptosis in C-elegans by the BarH homeodomain protein CEH-30 and the transcriptional repressor UNC-37/Groucho 2007
• The enhancement of pericentromeric cohesin association by conserved kinetochore components promotes high-fidelity chromosome segregation and is sensitive to microtubule-based tension 2007
• Control of translation and mRNA degradation by miRNAs and siRNAs: Table 1. 2006
• Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program 2006
• Genetic redundancy masks diverse functions of the tumor suppressor gene PTEN during C-elegans development 2006
• Essential and separable roles for Syndecan-3 and Syndecan-4 in skeletal muscle development and regeneration 2004
• Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs 2003
• The transcriptional activity of human Chromosome 22 2003
• A bulged stem tethers Est1p to telomerase RNA in budding yeast 2002
• Human CRSP interacts with RNA polymerase IICTD and adopts a specific CTD-bound conformation 2002
• fzr-1 and lin-35/Rb function redundantly to control cell proliferation in C-elegans as revealed by a nonbiased synthetic screen 2002
• The RNA-binding protein Tsunagi interacts with Mago Nashi to establish polarity and localize oskar mRNA during Drosophila oogenesis 2001
• A complex containing CstF-64 and the SL2 snRNP connects mRNA 3′ end formation and trans-splicing in C. elegans operons 2001
• A novel embryonic poly(A) binding protein, ePAB, regulates mRNA deadenylation in Xenopus egg extracts 2001
• Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins 2000
• The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf 2000
• Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants 1999
• A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction 1999
• A G-protein signaling network mediated by an RGS protein 1999
• Synergistic cooperation of TFE3 and Smad proteins in TGF-β-induced transcription of the plasminogen activator inhibitor-1 gene 1998
• Exit from mitosis in Drosophila syncytial embryos requires proteolysis and cyclin degradation, and is associated with localized dephosphorylation. 1998
• Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha 1998
• Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage 1997
• Repression of p53-mediated transcription by MDM2: a dual mechanism 1997
• ELT-1, a GATA-like transcription factor, is required for epidermal cell fates in Caenorhabditis elegans embryos. 1997
• The anticodon is the signal sequence for mitochondrial import of glutamine tRNA in Tetrahymena 1996
• The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease 1996
• Multiple functions for the poly(A)-binding protein in mRNA decapping and deadenylation in yeast. 1995
• SUR-2, A NOVEL GENE, FUNCTIONS LATE IN THE LET-60 RAS-MEDIATED SIGNALING PATHWAY DURING CAENORHABDITIS-ELEGANS VULVAR INDUCTION 1995
• HNRNP-L BINDS A CIS-ACTING RNA SEQUENCE ELEMENT THAT ENABLES INTRON-INDEPENDENT GENE-EXPRESSION 1995
• MEK-2, A CAENORHABDITIS-ELEGANS MAP KINASE KINASE, FUNCTIONS IN RAS-MEDIATED VULVAR INDUCTION AND OTHER DEVELOPMENTAL EVENTS 1995
• TELOMERASE RNAS OF DIFFERENT CILIATES HAVE A COMMON SECONDARY STRUCTURE AND A PERMUTED TEMPLATE 1994
• A TERTIARY INTERACTION IN THE TETRAHYMENA INTRON CONTRIBUTES TO SELECTION OF THE 5' SPLICE-SITE 1994
• Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript. 1994
• Transcription factor IIE binds preferentially to RNA polymerase IIa and recruits TFIIH: a model for promoter clearance. 1994
• RECOGNITION OF THE MESSENGER-RNA SELENOCYSTEINE INSERTION-SEQUENCE BY THE SPECIALIZED TRANSLATIONAL ELONGATION-FACTOR SELB 1994
• SUPPRESSION OF ACTIVATED LET-60 RAS PROTEIN DEFINES A ROLE OF CAENORHABDITIS-ELEGANS SUR-1 MAP KINASE IN VULVAR DIFFERENTIATION 1994
• Drosophila TFIIA-L is processed into two subunits that are associated with the TBP/TAF complex. 1993
• A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation. 1993
• OXYTRICHA TELOMERE-BINDING PROTEIN - SEPARABLE DNA-BINDING AND DIMERIZATION DOMAINS OF THE ALPHA-SUBUNIT 1993
• Mutations affecting stability and deadenylation of the yeast MFA2 transcript. 1992
• THE REX SYSTEM OF BACTERIOPHAGE-LAMBDA - TOLERANCE AND ALTRUISTIC CELL-DEATH 1992
• ANALYSIS OF DOMINANT-NEGATIVE MUTATIONS OF THE CAENORHABDITIS-ELEGANS LET-60 RAS GENE 1991
• TUDOR, A POSTERIOR-GROUP GENE OF DROSOPHILA-MELANOGASTER, ENCODES A NOVEL PROTEIN AND AN MESSENGER-RNA LOCALIZED DURING MID-OOGENESIS 1991
• BINDING OF THE CBP2 PROTEIN TO A YEAST MITOCHONDRIAL GROUP-I INTRON REQUIRES THE CATALYTIC CORE OF THE RNA 1991
• THE PHAGE-T4 NRDB INTRON - A DELETION MUTANT OF A VERSION FOUND IN THE WILD 1991
• DOMAINS OF INITIATOR TRANSFER-RNA AND INITIATION CODON CRUCIAL FOR INITIATOR TRANSFER-RNA SELECTION BY ESCHERICHIA-COLI IF3 1990
• SELECTION OF THE INITIATOR TRANSFER-RNA BY ESCHERICHIA-COLI INITIATION-FACTORS 1989
• DETERMINANTS OF THE 3' SPLICE SITE FOR SELF-SPLICING OF THE TETRAHYMENA PRE-RRNA 1988
• DELETION OF NONCONSERVED HELICES NEAR THE 3' END OF THE RIBOSOMAL-RNA INTRON OF TETRAHYMENA-THERMOPHILA ALTERS SELF-SPLICING BUT NOT CORE CATALYTIC ACTIVITY 1988
• TELOMERIC DNA PROTEIN INTERACTIONS OF OXYTRICHA MACRONUCLEAR DNA 1987
• A trans-acting suppressor restores splicing of a yeast intron with a branch point mutation. 1987

Research

keywords

• 06 Biological Sciences, 11 Medical and Health Sciences, 17 Psychology and Cognitive Sciences