Genes and Development
Overview
publication venue for
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Learning from the worm: the effectiveness of protein-bound Moco to treat Moco deficiency
2021
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Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription
2020
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Structure and mechanism of the RNA polymerase II transcription machinery
2020
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Regulation of histone methylation by automethylation of PRC2
2019
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Is it time to take R(epressive) out of PRC1?
2019
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Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits
2018
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Neat1 is a p53-inducible lincRNA essential for transformation suppression
2017
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Finding the start site: redefining the human initiator element
2017
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Targeted CRISPR disruption reveals a role for RNase MRP RNA in human preribosomal RNA processing
2017
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Time to move the fat
2016
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Nucleotide levels regulate germline proliferation through modulating GLP-1/Notch signaling in C. elegans
2016
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Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers
2015
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Intestinal apical polarity mediates regulation of TORC1 by glucosylceramide in C. elegans
2015
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Human telomerase: biogenesis, trafficking, recruitment, and activation
2015
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linc-HOXA1 is a noncoding RNA that represses Hoxa1 transcription in cis
2013
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Fat chance for longevity
2013
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The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator
2013
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FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2
2012
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Delta Np63 alpha represses anti-proliferative genes via H2A.Z deposition
2012
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The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling (vol 26, pg 803, 2012)
2012
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RNase P branches out from RNP to protein: organelle-triggered diversification?
2012
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The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling
2012
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Quantitative functions of Argonaute proteins in mammalian development
2012
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Regulation of maternal phospholipid composition and IP3-dependent embryonic membrane dynamics by a specific fatty acid metabolic event in C. elegans
2012
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Suppression of progenitor differentiation requires the long noncoding RNA ANCR
2012
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Phactr4 regulates directional migration of enteric neural crest through PP1, integrin signaling, and cofilin activity
2012
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Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses
2011
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HEB and E2A function as SMAD/FOXH1 cofactors
2011
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The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity
2011
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Polycistronic pre-mRNA processing in vitro: snRNP and pre-mRNA role reversal in trans-splicing
2010
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Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding
2010
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Functional interaction between telomere protein TPP1 and telomerase
2010
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Differential regulation of p53 target genes: it's (core promoter) elementary
2010
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Human POT1 is required for efficient telomere C-rich strand replication in the absence of WRN
2009
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A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint
2009
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Nucleosome-binding affinity as a primary determinant of the nuclear mobility of the pioneer transcription factor FoxA
2009
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The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function
2009
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Histone H2B ubiquitination: the cancer connection
2008
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A branched-chain fatty acid is involved in post-embryonic growth control in parallel to the insulin receptor pathway and its biosynthesis is feedback-regulated in C-elegans
2008
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A dermal HOX transcriptional program regulates site-specific epidermal fate
2008
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Axin and GSK3-β control Smad3 protein stability and modulate TGF-β signaling
2008
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Axin and GSK3-β control Smad3 protein stability and modulate TGF-β signaling
2008
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Control of sex-specific apoptosis in C-elegans by the BarH homeodomain protein CEH-30 and the transcriptional repressor UNC-37/Groucho
2007
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The enhancement of pericentromeric cohesin association by conserved kinetochore components promotes high-fidelity chromosome segregation and is sensitive to microtubule-based tension
2007
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Control of translation and mRNA degradation by miRNAs and siRNAs: Table 1.
2006
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Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program
2006
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Genetic redundancy masks diverse functions of the tumor suppressor gene PTEN during C-elegans development
2006
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Essential and separable roles for Syndecan-3 and Syndecan-4 in skeletal muscle development and regeneration
2004
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Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
2003
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The transcriptional activity of human Chromosome 22
2003
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A bulged stem tethers Est1p to telomerase RNA in budding yeast
2002
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Human CRSP interacts with RNA polymerase IICTD and adopts a specific CTD-bound conformation
2002
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fzr-1 and lin-35/Rb function redundantly to control cell proliferation in C-elegans as revealed by a nonbiased synthetic screen
2002
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The RNA-binding protein Tsunagi interacts with Mago Nashi to establish polarity and localize oskar mRNA during Drosophila oogenesis
2001
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A complex containing CstF-64 and the SL2 snRNP connects mRNA 3′ end formation and trans-splicing in C. elegans operons
2001
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A novel embryonic poly(A) binding protein, ePAB, regulates mRNA deadenylation in Xenopus egg extracts
2001
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Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins
2000
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The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf
2000
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Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants
1999
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A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction
1999
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A G-protein signaling network mediated by an RGS protein
1999
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Synergistic cooperation of TFE3 and Smad proteins in TGF-β-induced transcription of the plasminogen activator inhibitor-1 gene
1998
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Exit from mitosis in Drosophila syncytial embryos requires proteolysis and cyclin degradation, and is associated with localized dephosphorylation.
1998
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Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha
1998
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Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage
1997
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Repression of p53-mediated transcription by MDM2: a dual mechanism
1997
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ELT-1, a GATA-like transcription factor, is required for epidermal cell fates in Caenorhabditis elegans embryos.
1997
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The anticodon is the signal sequence for mitochondrial import of glutamine tRNA in Tetrahymena
1996
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The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease
1996
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Multiple functions for the poly(A)-binding protein in mRNA decapping and deadenylation in yeast.
1995
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SUR-2, A NOVEL GENE, FUNCTIONS LATE IN THE LET-60 RAS-MEDIATED SIGNALING PATHWAY DURING CAENORHABDITIS-ELEGANS VULVAR INDUCTION
1995
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HNRNP-L BINDS A CIS-ACTING RNA SEQUENCE ELEMENT THAT ENABLES INTRON-INDEPENDENT GENE-EXPRESSION
1995
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MEK-2, A CAENORHABDITIS-ELEGANS MAP KINASE KINASE, FUNCTIONS IN RAS-MEDIATED VULVAR INDUCTION AND OTHER DEVELOPMENTAL EVENTS
1995
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TELOMERASE RNAS OF DIFFERENT CILIATES HAVE A COMMON SECONDARY STRUCTURE AND A PERMUTED TEMPLATE
1994
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A TERTIARY INTERACTION IN THE TETRAHYMENA INTRON CONTRIBUTES TO SELECTION OF THE 5' SPLICE-SITE
1994
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Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript.
1994
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Transcription factor IIE binds preferentially to RNA polymerase IIa and recruits TFIIH: a model for promoter clearance.
1994
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RECOGNITION OF THE MESSENGER-RNA SELENOCYSTEINE INSERTION-SEQUENCE BY THE SPECIALIZED TRANSLATIONAL ELONGATION-FACTOR SELB
1994
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SUPPRESSION OF ACTIVATED LET-60 RAS PROTEIN DEFINES A ROLE OF CAENORHABDITIS-ELEGANS SUR-1 MAP KINASE IN VULVAR DIFFERENTIATION
1994
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Drosophila TFIIA-L is processed into two subunits that are associated with the TBP/TAF complex.
1993
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A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation.
1993
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OXYTRICHA TELOMERE-BINDING PROTEIN - SEPARABLE DNA-BINDING AND DIMERIZATION DOMAINS OF THE ALPHA-SUBUNIT
1993
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Mutations affecting stability and deadenylation of the yeast MFA2 transcript.
1992
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THE REX SYSTEM OF BACTERIOPHAGE-LAMBDA - TOLERANCE AND ALTRUISTIC CELL-DEATH
1992
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ANALYSIS OF DOMINANT-NEGATIVE MUTATIONS OF THE CAENORHABDITIS-ELEGANS LET-60 RAS GENE
1991
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TUDOR, A POSTERIOR-GROUP GENE OF DROSOPHILA-MELANOGASTER, ENCODES A NOVEL PROTEIN AND AN MESSENGER-RNA LOCALIZED DURING MID-OOGENESIS
1991
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BINDING OF THE CBP2 PROTEIN TO A YEAST MITOCHONDRIAL GROUP-I INTRON REQUIRES THE CATALYTIC CORE OF THE RNA
1991
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THE PHAGE-T4 NRDB INTRON - A DELETION MUTANT OF A VERSION FOUND IN THE WILD
1991
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DOMAINS OF INITIATOR TRANSFER-RNA AND INITIATION CODON CRUCIAL FOR INITIATOR TRANSFER-RNA SELECTION BY ESCHERICHIA-COLI IF3
1990
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SELECTION OF THE INITIATOR TRANSFER-RNA BY ESCHERICHIA-COLI INITIATION-FACTORS
1989
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DETERMINANTS OF THE 3' SPLICE SITE FOR SELF-SPLICING OF THE TETRAHYMENA PRE-RRNA
1988
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DELETION OF NONCONSERVED HELICES NEAR THE 3' END OF THE RIBOSOMAL-RNA INTRON OF TETRAHYMENA-THERMOPHILA ALTERS SELF-SPLICING BUT NOT CORE CATALYTIC ACTIVITY
1988
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TELOMERIC DNA PROTEIN INTERACTIONS OF OXYTRICHA MACRONUCLEAR DNA
1987
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A trans-acting suppressor restores splicing of a yeast intron with a branch point mutation.
1987
Research
keywords
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06 Biological Sciences, 11 Medical and Health Sciences, 17 Psychology and Cognitive Sciences