A therapeutic aptamer inhibits angiogenesis by specifically targeting the heparin binding domain of VEGF165
Journal Article
Overview
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Aptamers, Nucleotide
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Binding Sites
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Binding Sites - Binding, Competitive
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Biochemical Phenomena - Binding, Competitive
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Biochemical Phenomena - Protein Binding
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Biochemical Phenomena - Signal Transduction
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Biological Factors - Vascular Endothelial Growth Factor A
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Biomedical and Dental Materials - Polyethylene Glycols
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Cell Physiological Phenomena - Signal Transduction
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Cells, Cultured
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Chemical Phenomena - Dimerization
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Chemistry Techniques, Analytical - Binding, Competitive
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Endothelium - Endothelium, Vascular
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Ethylene Glycols - Polyethylene Glycols
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Heparin
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Humans
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Macromolecular Substances - Polyethylene Glycols
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Macular Degeneration
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Magnetic Resonance Spectroscopy
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Manufactured Materials - Polyethylene Glycols
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Metabolism - Dimerization
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Metabolism - Protein Binding
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Models, Molecular
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Neovascularization, Pathologic
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Peptides - Vascular Endothelial Growth Factor A
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Protein Conformation
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Protein Isoforms
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Protein Structure, Secondary
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Protein Structure, Tertiary
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Proteins - Vascular Endothelial Growth Factor A
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Pyrimidines
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RNA
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Saccharomycetales - Pichia
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Thermodynamics
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Tunica Intima - Endothelium, Vascular
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Yeasts - Pichia
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Date in CU Experts
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September 9, 2013 9:19 AM
Full Author List
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Lee JH; Canny MD; De Erkenez A; Krilleke D; Ng YS; Shima DT; Pardi A; Jucker F
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