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Pardi, Arthur Professor

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Research

research overview

  • Dr. Pardi's research focuses on structure-function studies of proteins, nucleic acids and nucleic aicd-protein complexes. Nucleic acid systems currently being studied in the lab include the hammerhead self-cleaving catalytic RNA and various DNA or RNA aptamers that bind with extremely high affinity to the angiogenic regulatory protein VEGF. Nuclear magnetic resonance and other biophysical techniques are used to probe the folding, structure and dynamics of various macromolecules and complexes.

keywords

  • RNA structure-function,protein structure and function, biophysical chemistry, nucleic acid biochemistry, nuclear magnetic resonance spectroscopy, single molecule spectroscopy

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