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Pardi, Arthur Professor

Positions

Research Areas research areas

Research

research overview

  • Dr. Pardi's research focuses on structure-function studies of proteins, nucleic acids and nucleic aicd-protein complexes. Nucleic acid systems currently being studied in the lab include the hammerhead self-cleaving catalytic RNA and various DNA or RNA aptamers that bind with extremely high affinity to the angiogenic regulatory protein VEGF. Nuclear magnetic resonance and other biophysical techniques are used to probe the folding, structure and dynamics of various macromolecules and complexes.

keywords

  • RNA structure-function,protein structure and function, biophysical chemistry, nucleic acid biochemistry, nuclear magnetic resonance spectroscopy, single molecule spectroscopy

Publications

selected publications

Teaching

courses taught

  • CHEM 4491 - Modern Biophysical Methods
    Primary Instructor - Fall 2018
    Covers the basic theory of biophysical methods widely employed in biochemistry and biology, including: electrophoresis, mass spec, calorimetry, evanescent waves, plasmon resonance, Xray diffraction, absorbance and fluorescence spectroscopy, magnetic resonance, electron and optical microscopy and single molecule methods. Discusses ways to maximize rigor and reproducibility in biophysical studies. Department enforced prerequisites: undergraduate chemistry (general, organic physical); physics; calculus. Same as BCHM 5491.
  • CHEM 5491 - Modern Biophysical Methods
    Primary Instructor - Fall 2018
    Covers the basic theory of biophysical methods widely employed in biochemistry and biology, including: electrophoresis, mass spec, calorimetry, evanescent waves, plasmon resonance, Xray diffraction, absorbance and fluorescence spectroscopy, magnetic resonance, electron and optical microscopy and single molecule methods. Discusses ways to maximize rigor and reproducibility in biophysical studies. Department enforced prerequisites: undergraduate chemistry (general, organic physical); physics; calculus. Same as BCHM 4491.
  • CHEM 6901 - Research in Chemistry
    Primary Instructor - Spring 2018 / Summer 2018 / Fall 2018 / Spring 2019 / Summer 2019
    May be repeated up to 15 total credit hours.

Background

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