The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice
Journal Article
Overview
publication date
- December 15, 2014
has subject area
- Aging
- Animals
- Biological Factors - Tumor Necrosis Factor-alpha
- Biological Factors - Tumor Necrosis Factor-alpha
- Blood Proteins - Tumor Necrosis Factor-alpha
- Cyclic N-Oxides
- Cyclooxygenase 2
- DNA-Binding Proteins - NF-kappa B
- Endothelium - Endothelium, Vascular
- Flavoproteins - NADPH Oxidase 4
- Flavoproteins - NADPH Oxidases
- Group III Histone Deacetylases - Sirtuin 1
- Heterocyclic Compounds, 4 or More Rings
- Inflammation
- Inorganic Chemicals - Nitric Oxide
- Male
- Membrane Proteins - NADPH Oxidase 4
- Membrane Proteins - NADPH Oxidases
- Mice
- Molecular Mechanisms of Pharmacological Action - Antioxidants
- Multiprotein Complexes - NF-kappa B
- NADH, NADPH Oxidoreductases - NADPH Oxidase 4
- NADH, NADPH Oxidoreductases - NADPH Oxidases
- Nitrogen Compounds - Nitric Oxide
- Nitrogen Compounds - Nitric Oxide
- Nuclear Proteins - NF-kappa B
- Oxygen Compounds - Nitric Oxide
- Peptides - Tumor Necrosis Factor-alpha
- Peptides - Tumor Necrosis Factor-alpha
- Physiological Effects of Drugs - Antioxidants
- Proteins - Sirtuin 1
- Proteins - Tumor Necrosis Factor-alpha
- Proteins - Tumor Necrosis Factor-alpha
- Proteins - Tumor Necrosis Factor-alpha
- Specialty Uses of Chemicals - Antioxidants
- Spin Labels
- Transcription Factors - NF-kappa B
- Tunica Intima - Endothelium, Vascular
- Vasodilation
has restriction
- green
Date in CU Experts
- October 31, 2014 4:44 AM
Full Author List
- Gano LB; Donato AJ; Pasha HM; Hearon CM; Sindler AL; Seals DR
author count
- 6
citation count
- 130
published in
Other Profiles
International Standard Serial Number (ISSN)
- 0363-6135
Electronic International Standard Serial Number (EISSN)
- 1522-1539
Digital Object Identifier (DOI)
Additional Document Info
start page
- H1754
end page
- H1763
volume
- 307
issue
- 12