• Contact Info
Publications in VIVO

Seals, Doug Distinguished Professor


Research Areas research areas


research overview

  • The research goals of the Integrative Physiology of Aging Laboratory are to determine: 1) important changes in physiological function with aging; 2) modulation of those changes by biological factors and lifestyle behaviors (e.g., physical activity/inactivity, diet); 3) the efficacy of lifestyle and pharmacological interventions for reversing adverse changes in physiological function with aging; 4) the integrative (systemic to molecular) biological mechanisms that mediate physiological changes with aging and the effects of modulating influences and interventions on those changes. Our primary focus is 'vascular aging', in particular the development of large elastic artery stiffness and impaired arterial endothelial function with advancing age. A wide range of contemporary experimental techniques are employed to study these issues in human subjects, rodents, and cell culture.


  • vascular aging, mechanisms of vascular aging, strategies for the prevention and treatment of vascular aging


selected publications


courses taught

  • IPHY 3590 - Health and Function over the Adult Lifespan
    Primary Instructor - Fall 2019
    Examines topics in the field of biomedical aging in the context of public health including: lifespan, changing demographics of aging, healthspan, genetics of aging; physiology of aging (changes in function with age; biological mechanisms of aging); clinical disorders of aging (aging and chronic diseases; clinical syndromes in geriatric medicine); lifestyle and pharmacological strategies for preserving health and function with aging.
  • IPHY 4870 - Honors Thesis
    Primary Instructor - Spring 2018 / Spring 2019 / Spring 2020
    Department enforced prerequisites: IPHY 2800 and IPHY 3700.
  • IPHY 4930 - Internship
    Primary Instructor - Spring 2018 / Summer 2018 / Spring 2019 / Summer 2019
    Provides an opportunity for field/laboratory work in a variety of different settings. Consult with faculty for approval. May be repeated up to 6 total credit hours. Department enforced prerequisite: completion of at least two of the major core classes.
  • IPHY 6010 - Seminar
    Primary Instructor - Fall 2018
    Presents special topics in integrative physiology. May be repeated up to 6 total credit hours.
  • IPHY 6840 - Research Project
    Primary Instructor - Spring 2018 / Summer 2018 / Fall 2018 / Spring 2019 / Summer 2019 / Fall 2019 / Spring 2020
    Involves a scholarly investigation of a selected topic using literature and/or experimental techniques. Advisor required. May be repeated up to 3 total credit hours.
  • IPHY 6950 - Master's Thesis
    Primary Instructor - Fall 2019 / Spring 2020
    Must have 4 credit hours and may be repeated up to 6 total credits.


awards and honors

Other Profiles