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Publications in VIVO

Seals, Douglas R Distinguished Professor


Research Areas research areas


research overview

  • The research goals of the Integrative Physiology of Aging Laboratory are to determine: 1) important changes in physiological function with aging; 2) modulation of those changes by biological factors and lifestyle behaviors (e.g., physical activity/inactivity, diet); 3) the efficacy of lifestyle and pharmacological interventions for reversing adverse changes in physiological function with aging; 4) the integrative (systemic to molecular) biological mechanisms that mediate physiological changes with aging and the effects of modulating influences and interventions on those changes. Our primary focus is 'vascular aging', in particular the development of large elastic artery stiffness and impaired arterial endothelial function with advancing age. A wide range of contemporary experimental techniques are employed to study these issues in human subjects, rodents, and cell culture.


  • vascular aging, mechanisms of vascular aging, strategies for the prevention and treatment of vascular aging


selected publications


courses taught


awards and honors