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Stowell, Michael Associate Professor

Positions

Research Areas research areas

Research

research overview

  • Our research is focused on molecular and supramolecular structures that facilitate communication between neurons at the chemical synapse and how such structures are perturbed in neurological disease. We are particularly interested in the architectural arrangement of signaling molecules and enzymes, and characterizing the ways in which such molecular assemblies are formed and undergo changes during synaptic transmission and modulation. Our approach is to investigate individual proteins using x-ray and electron crystallographic methods and to combine this information with EM images obtained via 3-D reconstruction of supramolecular assemblies and tomographic analysis of the intact chemical synapse. Our long-term goal is to construct a dynamic molecular and architectural map for the chemical synapse that will help to understand synaptic formation, transmission and plasticity

keywords

  • alzheimer's disease, neurodegenerative diseases/disorders, membrane proteins, electron microscopy

Publications

selected publications

Teaching

courses taught

  • MCDB 6000 Introduction to Laboratory Methods (Spring 2019)
  • MCDB 8990 Doctoral Dissertation (Spring 2019)
  • MCDB 4840 Upper-Division Independent Study (Fall 2018)
  • MCDB 4980 Honors Research (Fall 2018)
  • MCDB 4990 Honors Thesis (Fall 2018)
  • MCDB 8990 Doctoral Dissertation (Fall 2018)
  • MCDB 3651 The Brain: Dysfunction to Disease (Spring 2018)
  • MCDB 6000 Introduction to Laboratory Methods (Spring 2018)
  • MCDB 8990 Doctoral Dissertation (Spring 2018)

Background

International Activities

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