A detailed understanding of cellular function (and dysfunction) requires an understanding of the mechanisms by which individual reactions interact and organize themselves to sustain the higher-order biochemical processes that constitute cellular “life.” My group studies these mechanisms of interaction and organization (temporal and spatial) and uses them to interrogate, control, and rewire biochemical networks of relevance to human health, energy, and the environment. My research program has three broad goals: (i) to develop physical and biochemical methods to study and control the activities of enzymes of metabolic relevance, (ii) to employ those methods to answer fundamental questions of cellular metabolism, human disease, and molecular recognition, and (iii) to apply those methods, and correspondingly evolved theories, to develop novel enzyme inhibitors and protein therapeutics, and to engineer biosynthetic pathways for the production of fuels and chemicals.
CHEN 1211 - General Chemistry for Engineers
One-semester lecture and recitation course designed to meet the general chemistry requirement for engineering students. Topics include stoichiometry; thermodynamics; gases, liquids, and solids; equilibrium; acids and bases; bonding concepts; kinetics; reactions; and materials science. Examples and problems illustrate the application of chemistry to engineering sub-disciplines. Department enforced prerequisites: one year of high school chemistry or CHEM 1021 (min. grade C-) and high school algebra. Recommended corequisite: CHEM 1221. Not recommended for students with grade below B- in CHEM 1021. Credit not granted for this course and CHEM 1113 or CHEM 1114 or CHEM 1400 or MCEN 1024.