Hammerhead redux: does the new structure fit the old biochemical data? Journal Article uri icon

Overview

abstract

  • The cleavage rates of 78 hammerhead ribozymes containing structurally conservative chemical modifications were collected from the literature and compared to the recently determined crystal structure of the Schistosoma mansoni hammerhead. With only a few exceptions, the biochemical data were consistent with the structure, indicating that the new structure closely resembles the transition state of the reaction. Since all the biochemical data were collected on minimal hammerheads that have a very different structure, the minimal hammerhead must be dynamic and occasionally adopt the quite different extended structure in order to cleave.

publication date

  • April 1, 2008

Date in CU Experts

  • March 13, 2015 12:56 PM

Full Author List

  • Nelson JA; Uhlenbeck OC

author count

  • 2

citation count

  • 27

published in

  • RNA  Journal

Other Profiles

International Standard Serial Number (ISSN)

  • 1355-8382

Electronic International Standard Serial Number (EISSN)

  • 1469-9001

Additional Document Info

start page

  • 605

end page

  • 615

volume

  • 14

issue

  • 4