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Xue, Ding Professor

Positions

Research Areas research areas

Research

research overview

  • Dr. Xue's research interests lie in studying the mechanisms of programmed cell death (or apoptosis), phospholipid asymmetry in biological membranes, mitochondrial inheritance, and radiation-induced bystander effects, as well as various human diseases associated with abnormalities in these fundamental biological processes. His laboratory has been using molecular genetic, biochemical, cell biological, pharmacological, and structural biological approaches to study the mechanisms that regulate and execute these important cellular and developmental processes in the nematode C. elegans and in mammals. Dr. Xue’s group also uses C. elegans as an animal model to study and carry out drug discovery to treat other human diseases, including analyses of the mechanisms underlying liver cell death and pathogenesis caused by infection of hepatitis B virus and development of therapeutic strategies to eradicate hepatitis B virus and halt disease progression.

keywords

  • apoptosis, necrosis, genetics, developmental biology, lipid asymmetry, hepatitis B virus, mitochondrial and ER signaling, mitochondrial inheritance, drug screens, biochemistry, cell biology, genome editing, radiation-induced bystander effects, neurodegenerative disorders

Publications

selected publications

Teaching

courses taught

  • CHEM 6901 - Research in Chemistry
    Primary Instructor - Spring 2018 / Summer 2018 / Fall 2018 / Spring 2019 / Summer 2019
    May be repeated up to 15 total credit hours.
  • MCDB 4426 - Cell Signaling and Developmental Regulation
    Primary Instructor - Spring 2018 / Spring 2019
    Introduces several cell signaling processes and their biological functions. Students read and analyze original research articles to learn the thinking processes of scientific research. Writing assignments and oral presentations are required. Fulfills MCDB scientific reasoning requirement. Recommended prerequisites: MCDB 3135 and MCDB 3145 and CHEM 4700 (minimum grade C-). Same as MCDB 5426.
  • MCDB 4980 - Honors Research
    Primary Instructor - Fall 2019
    Provides faculty-supervised research for students who have been approved by the departmental honors committee. Normally taken during the semester before completion of the honors thesis. Recommended prerequisite: MCDB 4840 or comparable research experience, and minimum GPA of 3.20.
  • MCDB 4990 - Honors Thesis
    Primary Instructor - Fall 2019
    Involves the preparation and defense of an honors thesis, based on faculty-supervised original research, including final phases of the research project. Recommended prerequisites: MCDB 4840 or MCDB 4980 or comparable research experience, and minimum GPA of 3.3 and approval by the MCDB Honors Committee.
  • MCDB 5426 - Cell Signaling and Developmental Regulation
    Primary Instructor - Spring 2018 / Spring 2019
    Introduces several cell signaling processes and their biological functions. Students read and analyze original research articles to learn the thinking processes of scientific research. Writing assignments and oral presentations are required. Same as MCDB 4426.
  • MCDB 6000 - Introduction to Laboratory Methods
    Primary Instructor - Spring 2018 / Spring 2019
    Introduces methodology and techniques used in biological research. Designed as a tutorial between a few students and one faculty member. Students are expected to read original research papers, discuss findings, and to plan and execute experiments in selected areas. Open only to MCDB graduate students. May be repeated up to 9 total credit hours.

Background

awards and honors

International Activities

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