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Borden, Mark A Professor

Positions

Research Areas research areas

Research

research overview

  • My research group investigates colloids and membranes with a focus on biomedical applications. Our strength is design and engineering of novel microbubble formulations for medical imaging, drug delivery, gene therapy and blood gas delivery. Microbubbles are stabilized spherical gas particles that are smaller than a red blood cell. For example, we are researching (1) targeted microbubbles for ultrasound molecular imaging, with a focus on evaluating tumor perfusion and angiogenesis and reducing the immunogenicity, (2) surface engineered microbubbles for multi-modality imaging, (3) multi-functional microbubbles for image-guided drug delivery, and (4) microbubble foams for intravenous oxygen delivery. We also specialize in colloidal and interfacial science aspects of microbubbles and other emulsions. For example, we are researching (1) the mechanical properties of the thin lipid film that coats microbubbles, emulsions and lung alveoli, and (2) factors that affect emulsion stability.

keywords

  • contrast agents, theranostics, colloids, biocolloids, emulsions, foams, microbubbles, image-guided drug delivery, targeted gene therapy, intravenous oxygen delivery

Publications

selected publications

Teaching

courses taught

  • BMEN 2000 - Introduction to Biomedical Engineering
    Primary Instructor - Spring 2019
    Reviews important aspects of biology and develops a basic understanding of the biomedical engineering field. Topics include physiological principles, biomechanics, bioinstrumentation, bioimaging, biotechnology and biomaterials. Recommended prerequisite: high school biology.
  • MCEN 3022 - Heat Transfer
    Primary Instructor - Fall 2018
    Studies fundamentals of heat transfer by conduction, convection, and radiation. Emphasizes problem formulation and selection of appropriate solution techniques. Provides applications to modern engineering systems, which may include energy, biological, environmental, and materials engineering problems.
  • MCEN 4228 - Special Topics in Mechanical Engineering
    Secondary Instructor - Fall 2019
    Subject matter to be selected from topics of current interest. May be repeated up to 15 credit hours. Same as MCEN 5228.
  • MCEN 5228 - Special Topics in Mechanical Engineering
    Secondary Instructor - Fall 2019
    Subject matter to be selected from topics of current interest. May be repeated up to 15 credit hours. Same as MCEN 4228.
  • MCEN 6228 - Special Topics
    Primary Instructor - Spring 2018

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